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Biocatalytic production of chiral pharmaceutical intermediates
被引：30
|作者：
Mahmoudian, M
[1
]
机构：
[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
关键词：
nucleoside oxidase;
savinase (TM);
uridine phosphorylase;
purine nucleoside phosphorylase;
ziagen (TM) (abacavir);
506U78;
regioselective acylation;
anti-inflammatory;
anti-viral and anti-leukaemic agents;
fermentation scale up;
D O I：
10.3109/10242420009015240
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
Biocatalytic production of several key chiral intermediates in the synthesis of anti-inflammatory, anti-viral and anti-leukaemic agents is described. These include (i) a nucleoside oxidase from Stenotrophomonas maltophilia to oxidise unnatural purine nucleosides, (ii) a serine-type protease from an alkalophilic Bacillus sp. to resolve racemic N-substituted lactams, and (iii) a co-immobilised uridine phosphorylase and purine nucleoside phosphorylase preparation from recombinant E. coli strains that catalyse base transfer reactions.
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页码：105 / 118
页数：14
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