α-Methylacyl-CoA racemase (AMACR) serves as a prognostic biomarker for the early recurrence/metastasis of HCC

被引:16
作者
Xu, Bo [1 ,2 ,3 ]
Cai, Zhixiong [2 ,3 ]
Zeng, Yongyi [1 ,2 ,3 ]
Chen, Lihong [2 ,3 ,4 ]
Du, Xiaobo [5 ]
Huang, Aimin [2 ,3 ,4 ]
Liu, Xiaolong [2 ,3 ]
Liu, Jingfeng [1 ,2 ,3 ]
机构
[1] Fujian Med Univ, Affiliated Hosp 1, Liver Dis Ctr, Fuzhou 350025, Fujian Province, Peoples R China
[2] Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Fujian Province, Peoples R China
[3] Fujian Med Univ, Liver Ctr Fujian Prov, Fuzhou 350025, Fujian Province, Peoples R China
[4] Fujian Med Univ, Sch Basic Med Sci, Dept Pathol, Fuzhou 350025, Fujian Province, Peoples R China
[5] First Peoples Hosp Yueyang, Dept Urol, Yueyang, Peoples R China
基金
中国国家自然科学基金;
关键词
HUGE HEPATOCELLULAR-CARCINOMA; COENZYME-A RACEMASE; PROSTATE-CANCER; DIFFERENTIAL EXPRESSION; MOLECULAR MARKER; TUMOR THROMBUS; RESECTION; OVEREXPRESSION; HEPATECTOMY; OUTCOMES;
D O I
10.1136/jclinpath-2014-202378
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Aims Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it is still lacking effective prognostic biomarkers so far. Previous results of the iTRAQ-based quantitative proteomics study (iTRAQ-2DLC-MS/MS) have shown that alpha-methylacyl-CoA racemase (AMACR) might be a promising prognostic biomarker for the early recurrence/metastasis of hepatocellular carcinoma (HCC). Here a large-scale cohort clinical study was performed to evaluate its prognostic potential. Methods HCC samples from patients (n=158) were used for the construction of tissue microarray. The expression level of AMACR was determined by immunohistochemical staining. A large-scale cohort clinical study between the expression of AMACR and some major clinical parameter has been performed to assess the prognostic potential of AMACR for the early recurrence/metastasis of HCC. Results Some important clinical parameters such as alpha-fetoprotein, tumour numbers, dissemination to regional lymph nodes, tumour capsule and portal vein tumour thrombosis are significantly associated with the low expression of AMACR. The expression of AMACR was an independent factor for the survival of patients with HCC. The median survival time was 17 months in the low-expression group compared with 45 months in the high-expression group. Conclusions This study reveals that the AMACR might be a potential prognostic marker for predicting early recurrence/metastasis of HCC after hepatectomy.
引用
收藏
页码:974 / 979
页数:6
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