Alanyl-aminopeptidase activity decrease in cerebrospinal fluid of Alzheimer patients

被引:5
作者
Iribar, MC
Montes, J
Maldonado, RG
Peinado, JM
机构
[1] Univ Granada, Sch Med, Inst Neurosci, Dept Biochem, E-18012 Granada, Spain
[2] Univ Granada, Sch Med, Inst Neurosci, Dept Med Neurol, E-18012 Granada, Spain
关键词
Alzheimer disease; amino acids; aminopeptidase; neurotoxicity; neuropeptides; protein degradation;
D O I
10.1159/000017021
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
We analyzed the amino acid concentrations and aminopeptidase activities in plasma and the cerebrospinal fluid (CSF) of Alzheimer patients. Correlations were calculated between these parameters and the degree of cognitive impairment, duration of the disease and age. In comparison with a control group, no changes were found in the levels of amino acids in CSF or plasma of Alzheimer patients. Alanyl-aminopeptidase activity was significantly lower in the CSF of Alzheimer patients, whereas no differences in CSF were detected as regards the remaining aminopeptidases. The plasma/CSF ratio for aminopeptidase activities was higher in AD patients than in controls, although the difference was only significant for alanyl-aminopeptidase. Amino acid ratios did not show this general tendency. The correlations between plasma aspartate and glutamate concentrations and the stage of the disease, measured with the Mini Mental State Examination, were studied. Changes in aminopeptidase activities and their role in protein dysfunction underlying Alzheimer disease are discussed.
引用
收藏
页码:44 / 49
页数:6
相关论文
共 30 条
  • [11] AN AMINOPEPTIDASE FROM MOUSE-BRAIN CYTOSOL THAT CLEAVES N-TERMINAL ACIDIC AMINO-ACID-RESIDUES
    KELLY, JA
    NEIDLE, EL
    NEIDLE, A
    [J]. JOURNAL OF NEUROCHEMISTRY, 1983, 40 (06) : 1727 - 1734
  • [12] ALZHEIMER PLAQUES AND TANGLES - ADVANCES ON BOTH FRONTS
    KOSIK, KS
    [J]. TRENDS IN NEUROSCIENCES, 1991, 14 (06) : 218 - 219
  • [13] KOWALL N W, 1987, Society for Neuroscience Abstracts, V13, P215
  • [14] PURIFICATION AND CHARACTERIZATION OF PYROGLUTAMYL AMINOPEPTIDASE FROM HUMAN CEREBRAL-CORTEX
    LAUFFART, B
    MCDERMOTT, JR
    BIGGINS, JA
    GIBSON, AM
    MANTLE, D
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (01) : 207 - 208
  • [15] LIPTON SA, 1994, NEW ENGL J MED, V330, P613
  • [16] COMPARISON OF AMINOPEPTIDASE, DIPEPTIDYL AMINOPEPTIDASE AND TRIPEPTIDYL AMINOPEPTIDASE ACTIVITIES IN BRAIN-TISSUE FROM NORMAL AND ALZHEIMERS-DISEASE CASES
    MANTLE, D
    PERRY, EK
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 98 (01) : 13 - 20
  • [17] COMPARISON OF MAJOR CORTICAL AMINOPEPTIDASE ACTIVITY IN NORMAL BRAIN AND BRAIN FROM PATIENTS WITH ALZHEIMERS-DISEASE
    MANTLE, D
    LAUFFART, B
    PERRY, EK
    PERRY, RH
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1989, 89 (2-3) : 227 - 234
  • [18] GLUTAMATE DYSFUNCTION IN ALZHEIMERS-DISEASE - AN HYPOTHESIS
    MARAGOS, WF
    GREENAMYRE, JT
    PENNEY, JB
    YOUNG, AB
    [J]. TRENDS IN NEUROSCIENCES, 1987, 10 (02) : 65 - 68
  • [19] CEREBROSPINAL-FLUID MICROGLIAL ANTIBODIES - POTENTIAL DIAGNOSTIC MARKERS FOR IMMUNE-MECHANISMS IN ALZHEIMERS-DISEASE
    MCRAE, A
    DAHLSTROM, A
    POLINSKY, R
    LING, EA
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1993, 57 (02) : 225 - 234
  • [20] MOUNTJOY CQ, 1988, HISTOL HISTOPATHOL, P74