Acute and chronic effects of aerobic exercise on blood pressure in resistant hypertension: study protocol for a randomized controlled trial

被引:16
作者
Nascimento, L. S. [1 ,2 ]
Santos, A. C. [1 ,2 ]
Lucena, J. M. S. [3 ]
Silva, L. G. O. [1 ]
Almeida, A. E. M. [1 ]
Brasileiro-Santos, M. S. [1 ,2 ]
机构
[1] Univ Fed Paraiba, Dept Educ Fis, Lab Estudos Treinamento Fis Aplicado Saude, Castelo Branco 1, BR-58051900 Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba, UPE, Programa Assoc Posgrad Educ Fis, Joao Pessoa, Paraiba, Brazil
[3] Univ Fed Tocantins, Campus Univ Tocantinopolis, BR-77900000 Tocantinopolis, Tocantins, Brazil
关键词
Hypertension; Exercise; Post-exercise hypotension; Autonomic nervous system; Hemodynamics; WATER-BASED EXERCISE; POSTEXERCISE HYPOTENSION; DYNAMIC EXERCISE; TRAINING INTENSITIES; MILD HYPERTENSION; PHYSICAL-ACTIVITY; EUROPEAN-SOCIETY; RESPONSES; VASODILATATION; HEMODYNAMICS;
D O I
10.1186/s13063-017-1985-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Resistant hypertension is a specific condition that affects approximately 10% of subjects with hypertension, and is characterized by persistently high blood pressure levels even using therapy of three or more antihypertensive agents or with blood pressure control using therapy with four or more antihypertensive agents. Changes in lifestyle, such as physical exercise, are indicated for controlling blood pressure. However, investigating studies about this therapy in individuals with resistant hypertension are few. Methods/design: This is a randomized controlled clinical trial. Forty-eight patients with resistant hypertension will be submitted to perform four short-term interventions: aerobic exercise sessions (mild-, moderate-and high-intensity) and control session, in random order and on separate days. After the short-term sessions, the patients will be randomly allocated into four groups for 8 weeks of follow-up: mild-, moderate-and high-intensity aerobic exercise, and a control group. The primary outcome is the occurrence of blood pressure reduction (office and ambulatory analysis, and acute and chronic effects). Secondary outcomes are autonomic and hemodynamic mechanisms: cardiac and vasomotor autonomic modulation, spontaneous baroreflex sensitivity, forearm blood flow and vascular resistance. Discussion: The importance of exercise for hypertension has been known for decades, but little is known about the effects on patients with resistant hypertension. This study will help to understand whether different aerobic exercise intensities can induce different responses, as well as by what mechanisms adjustments in blood pressure levels may occur.
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页数:8
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