Targeting molecular pathways in cancer stem cells by natural bioactive compounds

被引：55

作者：

Cianciosi, Danila ^{[1
]}

Varela-Lopez, Alfonso ^{[2
]}

Forbes-Hernandez, Tamara Y. ^{[1
]}

Gasparrini, Massimiliano ^{[1
]}

Afrin, Sadia ^{[1
]}

Reboredo-Rodriguez, Patricia ^{[1
,3
]}

Zhang, JiaoJiao ^{[1
]}

Quiles, Jose L. ^{[2
]}

Nabavi, Seyed F. ^{[4
]}

Battino, Maurizio ^{[1
]}

Giampieri, Francesca ^{[1
]}

机构：

[1] Univ Politecn Marche, Fac Med, Dept Clin Sci, I-60131 Ancona, Italy

[2] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Physiol, Granada, Spain

[3] Univ Vigo, Fac Sci, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain

[4] Kermanshah Univ Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Kermanshah, Iran

来源：

PHARMACOLOGICAL RESEARCH | 2018年 / 135卷

关键词：

Cancer stem cells; Chemoprevention; Natural compounds; Wnt; Notch; Hedgehog; COLON-CANCER; SELF-RENEWAL; WNT/BETA-CATENIN; DIETARY COMPOUND; ELLAGIC ACID; ANTICANCER ACTIVITY; SONIC HEDGEHOG; IN-VITRO; NOTCH; WNT;

D O I：

10.1016/j.phrs.2018.08.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer Stem Cells (CSCs) or Tumor-Initiating Cells (TICs) are a small sub-population of cells within the tumor, able to give chemio- and radio-resistance and cause the onset of metastasis and the presence of relapses; for these reasons, they are recently becoming a potential target for anticancer therapy. One of the main characteristics of these cells is the self-renewal through the capability of modulating different molecular signalling pathways, including Wnt/beta-Catenin, Sonic Hedgehog and Notch pathways. Natural bioactive compounds such as resveratrol, epigallocatechin, curcumin, quercetin, ellagic acid, anthocyanins and other compounds and extracts can have a direct or indirect effect on these molecular pathways, decreasing the pathological activities of CSCs. This review aims to report and summarize the in vitro and in vivo studies about the preventive, therapeutic and chemosensitizing effects of these natural bioactive compounds on CSCs deriving from different types of tumors.

引用

页码：150 / 165

页数：16

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