Metabolites from the Mangrove Endophytic Fungus Phomopsis sp (#zsu-H76)

被引：41

作者：

Yang, Jianxiang ^{[1
]}

Xu, Fang ^{[1
]}

Huang, Caihuan ^{[1
]}

Li, Jing ^{[1
]}

She, Zhigang ^{[1
]}

Pei, Zhong ^{[2
]}

Lin, Yongcheng ^{[1
]}

机构：

[1] Sun Yat Sen Zhongshan, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Zhongshan, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 19期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

Natural products; Structure elucidation; Lactones; Biological activity;

D O I：

10.1002/ejoc.201000329

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three unique metabolites, namely, phomopsis-H76 A (1), B (2), and C (3), were isolated from the mangrove endophytic fungus Phomopsis sp. (#zsu-H76). Structures were determined by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. Compound 1-3 are all dimers. Compounds 2 and 3 possesses a pyrano[4,3-b]pyran-5(2H)-one ring system that is unprecedented in nature. Primary bioassays showed that 1 accelerated the growth of subintestinal vessel plexus (SIV) branch markedly, whereas 3 showed inhibition of Sly. Compounds 1-3 showed no activity in antibacterial and cytotoxic tests.

引用

页码：3692 / 3695

页数：4

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