Metabolites from the Mangrove Endophytic Fungus Phomopsis sp (#zsu-H76)

被引：40

作者：

Yang, Jianxiang ^{[1
]}

Xu, Fang ^{[1
]}

Huang, Caihuan ^{[1
]}

Li, Jing ^{[1
]}

She, Zhigang ^{[1
]}

Pei, Zhong ^{[2
]}

Lin, Yongcheng ^{[1
]}

机构：

[1] Sun Yat Sen Zhongshan, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Zhongshan, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 19期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

Natural products; Structure elucidation; Lactones; Biological activity;

D O I：

10.1002/ejoc.201000329

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three unique metabolites, namely, phomopsis-H76 A (1), B (2), and C (3), were isolated from the mangrove endophytic fungus Phomopsis sp. (#zsu-H76). Structures were determined by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. Compound 1-3 are all dimers. Compounds 2 and 3 possesses a pyrano[4,3-b]pyran-5(2H)-one ring system that is unprecedented in nature. Primary bioassays showed that 1 accelerated the growth of subintestinal vessel plexus (SIV) branch markedly, whereas 3 showed inhibition of Sly. Compounds 1-3 showed no activity in antibacterial and cytotoxic tests.

引用

页码：3692 / 3695

页数：4

共 8 条

[1] Oblongolides from the Endophytic Fungus Phomopsis sp BCC 9789 [J].

Bunyapaiboonsri, Taridaporn ;

Yoiprommarat, Seangaroon ;

Srikitikulchai, Prasert ;

Srichomthong, Kitlada ;

Lumyong, Saisaimorn .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (01) :55-59

[2] Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp ZSU-H76 [J].

Huang, Zhongjing ;

Cai, Xiaoling ;

Shao, Changlun ;

She, Zhigang ;

Xia, Xuekui ;

Chen, Yiguang ;

Yang, Jianxiang ;

Zhou, Shining ;

Lin, Yongcheng .

PHYTOCHEMISTRY, 2008, 69 (07) :1604-1608

[3] New Bioactive 2,3-Epoxycyclohexenes and Isocoumarins from the Endophytic Fungus Phomopsis sp from Laurus Azorica [J].

Hussain, Hidayat ;

Akhtar, Nadeem ;

Draeger, Siegfried ;

Schulz, Barbara ;

Pescitelli, Gennaro ;

Salvadori, Piero ;

Antus, Sandor ;

Kurtan, Tibor ;

Krohn, Karsten .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 2009 (05) :749-756

[4] Five unique compounds:: Xyloketals from mangrove fungus Xylaria sp from the South China Sea coast [J].

Lin, YC ;

Wu, XY ;

Feng, SA ;

Jiang, GC ;

Luo, JH ;

Zhou, SN ;

Vrijmoed, LLP ;

Jones, EBG ;

Krohn, K ;

Steingröver, K ;

Zsila, F .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (19) :6252-6256

[5] Review of bioactive compounds from fungi in the South China Sea [J].

Pan, Jia-Hui ;

Jones, E. B. Gareth ;

She, Zhi-Gang ;

Pang, Ji-Yan ;

Lin, Yong-Cheng .

BOTANICA MARINA, 2008, 51 (03) :179-190

[6] Three Metabolites from the Mangrove Endophytic Fungus Sporothrix sp (#4335) from the South China Sea [J].

Wen, Lu ;

Cai, Xiaoling ;

Xu, Fang ;

She, Zhigang ;

Chan, Wing Lai ;

Vrijmoed, L. L. P. ;

Jones, E. B. G. ;

Lin, Yongcheng .

JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (03) :1093-1098

[7] Xyloketal F:: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp (#2508) from the South China Sea coast [J].

Wu, XY ;

Liu, XH ;

Lin, YC ;

Luo, JH ;

She, ZG ;

Li, HJ ;

Chan, WL ;

Antus, S ;

Kurtan, T ;

Elsässer, B ;

Krohn, K .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (19) :4061-4064

[8] New mono- and dimeric members of the secalonic acid family:: Blennolides A-G isolated from the Fungus Blennoria sp. [J].

Zhang, Wen ;

Krohn, Karsten ;

Ullah, Zia ;

Floerke, Ulrich ;

Pescitelli, Gennaro ;

Di Bari, Lorenzo ;

Antus, Sandor ;

Kurtan, Tibor ;

Rheinheimer, Joachim ;

Draeger, Siegfried ;

Schulz, Barbara .

CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (16) :4913-4923

← 1 →