Telomerase and the aging process

被引：78
作者：
Hornsby, Peter J.
机构：
[1] Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78245 USA
[2] Univ Texas, Hlth Sci Ctr, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2007年 / 42卷 / 07期
关键词：
telomerase; telomeres; senescence; cancer; immortalization;
D O I：
10.1016/j.exger.2007.03.007
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：575 / 581
页数：7
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