N-Phosphonyl/phosphinyl imines and group-assisted purification (GAP) chemistry/technology

被引：98

作者：

An, Guanghui ^{[1
,2
,3
]}

Seifert, Cole ^{[1
]}

Li, Guigen ^{[1
,2
]}

机构：

[1] Nanjing Univ, Inst Chem & BioMed Sci, Nanjing 210093, Jiangsu, Peoples R China

[2] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

[3] Heilongjiang Univ, Sch Chem & Mat Sci, Key Lab Funct Inorgan Mat Chem MOE, Harbin 150080, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 06期

关键词：

PHASE-PEPTIDE-SYNTHESIS; CHEMISTRY ASYMMETRIC-SYNTHESIS; REACTING PHOSPHONYL IMINES; EFFICIENT SYNTHESIS; OPIOID PEPTIDE; AMINO-ACIDS; CHROMATOGRAPHY; DESIGN; ESTERS; ENKEPHALINS;

D O I：

10.1039/c4ob02254h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of environmentally benign, operationally simple, and economically viable synthetic methodologies has been a great challenge in organic synthesis. Group-assisted purification (GAP) chemistry was established to enable the synthesis of organic compounds without using traditional purification technologies, such as column chromatography and recrystallization. This concept/technology should encourage the synthetic community to make more efforts on searching for environmentally benign reagents and reactions to reduce the waste generated from silica and solvents, particularly toxic solvents; also, to reduce production/synthesis expenses, manpower, and energy. This review will discuss the GAP concept/technology and related reactions that were mainly conducted in the PI's laboratories after 2010.

引用

页码：1600 / 1617

页数：18

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