Automated Micro-PIV measurement in Lab-on-a-Chip systems

被引：9

作者：

Busek, M. ^{[1
,2
]}

Polk, C. ^{[1
]}

Albrecht, T. ^{[1
]}

Marx, U. ^{[2
]}

Koenig, J. ^{[3
]}

Sonntag, F. ^{[1
]}

机构：

[1] Fraunhofer Inst Mat & Beam Technol IWS, Dresden, Germany

[2] TU Berlin, Inst Med Biotechnol, Berlin, Germany

[3] Tech Univ Dresden, Fac Elect & Comp Engn, Lab Measurement & Testing Tech, Dresden, Germany

来源：

BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2012年 / 57卷

关键词：

D O I：

10.1515/bmt-2012-4064

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Flow rate and wall shear stress are important parameters for perfused cell culture systems and should be monitored. An easy and non-invasive method is the particle image velocimetry (PIV). In this work PIV was used to characterize a cell culture system with included peristaltic pump. The time-dependent flow profile was measured on several points of the chip for different pumping speeds to figure out which forces are applied to dissolved and adherent cells. The results can be used to improve the developed pump in respect to its layout, the excitation and the position within the chip.

引用

页码：927 / 930

页数：4

共 9 条

[1] A LIVING SYSTEM ON A CHIP [J].

Baker, Monya .

NATURE, 2011, 471 (7340) :661-665

[2] Precise micro flow rate measurements by a laser Doppler velocity profile sensor with time division multiplexing [J].

Koenig, Joerg ;

Voigt, Andreas ;

Buettner, Lars ;

Czarske, Juergen .

MEASUREMENT SCIENCE AND TECHNOLOGY, 2010, 21 (07)

[3] A review of micropumps [J].

Laser, DJ ;

Santiago, JG .

JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2004, 14 (06) :R35-R64

[4]

Raffel M., 2001, Particle Image Velocimetry

[5]

Sonntag F., 2010, J BIOTECHNOLOGY, V148

[6]

Sonntag F., 2011, BIOSPEKTRUM, V4, P418, DOI DOI 10.1007/S12268-011-0067-6

[7]

Taylor Z., DFD08 M AM PHYS SOC

[8] A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture [J].

Wu, Min-Hsien ;

Huang, Song-Bin ;

Cui, Zhanfeng ;

Cui, Zheng ;

Lee, Gwo-Bin .

BIOMEDICAL MICRODEVICES, 2008, 10 (02) :309-319

[9] Diffusive spreading of time-dependent pressures in elastic microfluidic devices [J].

Wunderlich, Bernhard K. ;

Klessinger, Ulrich A. ;

Bausch, Andreas R. .

LAB ON A CHIP, 2010, 10 (08) :1025-1029

← 1 →