GABAB receptor mechanism and imipramine-induced antinociception in ligated and non-ligated mice

被引:24
|
作者
Zarrindast, MR
Valizadeh, S
Sahebgharani, M
机构
[1] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[2] Azad Univ, Tehran, Iran
关键词
baclofen; imipiramine; ligation; hot-plate test; (mouse);
D O I
10.1016/S0014-2999(00)00648-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study concerned the effects of GABA(B) receptor agents on imipramine-induced antinociception in ligated and non-ligated mice in hot-plate test. The data showed that different doses of morphine (3, 6 and 9 mg/kg) induced a dose-dependent antinociception in non-ligated or ligated mice. However, the opioid response was decreased in the ligated animals. Intracerebroventricular (i.c.v.) administration of imipramine (5, 10, 20 and 40 mug/mouse) did not induce antinociception in either non-ligated or ligated mice. However, the response induced in the ligated mice was less than that induced in the non-ligated animals. Intraperitoneal (i.p.) administration of imipramine (10, 20, 30 and 40 mg/kg) induced antinociception in both ligated and non-ligated animals. The responses to the drug were not significantly different in the two groups. Administration of baclofen either i.c.v. (0.125, 0.25 and 0.5 mug/mouse) or i.p. (0.5, 1, 2 and 4 mg/kg) induced antinociception. The response to the drug was not significantly different, in ligated and non-ligated mice. I.c.v. administration of a lower dose of baclofen (0.125 mug/mouse) with different doses of imipramine (2.5, 5 and 10 mg/kg) potentiates the response of imipramine. This effect was reduced by i.c.v. injection of GABA(B) receptor antagonist, CGP35348 [P-(3-aminopropyl)-p-diethoxymethyl-phosphinic acid] (20 mug/mouse). The higher dose of antagonist (20 mug/mouse) also decreased the response induced by baclofen or imipramine. CGP35348 itself (2.5, 5, 10 and 20 mug/mouse) induced dose-dependent antinociception with no significant difference in the ligated and non-ligated mice. It is concluded that a GABA receptor mechanism(s) may modulate the antidepressant-induced antinociception. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:65 / 72
页数:8
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