The Use of Colchicine in Cardiovascular Diseases: A Systematic Review

被引：20

作者：

Siak, Jessica ^{[1
]}

Flint, Nir ^{[2
]}

Shmueli, Hezzy G. ^{[2
]}

Siegel, Robert J. ^{[3
]}

Rader, Florian ^{[3
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

[2] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr Affil, Dept Cardiol, Sackler Fac Med, Tel Aviv, Israel

[3] Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol, Los Angeles, CA 90048 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2021年 / 134卷 / 06期

关键词：

Atrial fibrillation; Colchicine; Coronary artery disease; Pericarditis; Safety; C-REACTIVE PROTEIN; ACUTE CORONARY SYNDROME; OPEN-HEART-SURGERY; ATRIAL-FIBRILLATION; RECURRENT PERICARDITIS; MYOCARDIAL-INFARCTION; CONVENTIONAL THERAPY; DOUBLE-BLIND; PREVENTION; PLACEBO;

D O I：

10.1016/j.amjmed.2021.01.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The medicinal properties of colchicine have been recognized for centuries. Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders. In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1) pericarditis, 2) coronary artery disease, and 3) atrial fibrillation. We also discuss the safety, potential adverse effects, and common drug interactions that should be considered during use. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：735 / +

页数：11

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