Primary Graft Dysfunction: The Role of Aging in Lung Ischemia-Reperfusion Injury

被引：12

作者：

Roesel, Maximilian J. ^{[1
,2
]}

Sharma, Nirmal S. ^{[3
,4
]}

Schroeter, Andreas ^{[1
,5
]}

Matsunaga, Tomohisa ^{[1
,6
]}

Xiao, Yao ^{[1
]}

Zhou, Hao ^{[1
]}

Tullius, Stefan G. ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Div Transplant Surg & Transplant Surg Res Lab, Boston, MA 02115 USA

[2] Charite Univ med Berlin, Inst Med Immunol, Berlin, Germany

[3] Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA USA

[4] Harvard Med Sch, Dept Med, Boston, MA USA

[5] Hannover Med Sch, Dept Gen,Visceral & Transplant Surg, Regenerat Med & Expt Surg, Hannover, Germany

[6] Osaka Med & Pharmaceut Univ, Dept Urol, Osaka, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

aging; ischemia reperfusion injury; primary graft dysfunction; lung transplantation; senolytics; ISHLT WORKING GROUP; CONSENSUS GROUP STATEMENT; NEUTROPHIL EXTRACELLULAR TRAPS; CLINICAL RISK-FACTORS; DONOR AGE; EXTENDED-CRITERIA; INTERNATIONAL-SOCIETY; PERMEABILITY TRANSITION; IMMUNE-RESPONSE; UNITED NETWORK;

D O I：

10.3389/fimmu.2022.891564

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transplant centers around the world have been using extended criteria donors to remedy the ongoing demand for lung transplantation. With a rapidly aging population, older donors are increasingly considered. Donor age, at the same time has been linked to higher rates of lung ischemia reperfusion injury (IRI). This process of acute, sterile inflammation occurring upon reperfusion is a key driver of primary graft dysfunction (PGD) leading to inferior short- and long-term survival. Understanding and improving the condition of older lungs is thus critical to optimize outcomes. Notably, ex vivo lung perfusion (EVLP) seems to have the potential of reconditioning ischemic lungs through ex-vivo perfusing and ventilation. Here, we aim to delineate mechanisms driving lung IRI and review both experimental and clinical data on the effects of aging in augmenting the consequences of IRI and PGD in lung transplantation.

引用

页数：9

共 142 条

[1] VEGF-A and -C but not -B mediate increased vascular, permeability in preserved lung grafts [J].