Opioid-free anesthesia

被引：107

作者：

Beloeil, Helene ^{[1
,2
]}

机构：

[1] Univ Rennes, Inserm CIC 1414, F-35000 Rennes, France

[2] CHU Rennes, Unite Numecan, Anesthesia & Intens Care Dept, F-35000 Rennes, France

来源：

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY | 2019年 / 33卷 / 03期

关键词：

opioid-free anesthesia; opioid; ketamine; lidocaine; alpha; 2; agonists; TOTAL INTRAVENOUS ANESTHESIA; POSTOPERATIVE PAIN; BARIATRIC SURGERY; INTRAOPERATIVE DEXMEDETOMIDINE; TRACHEAL INTUBATION; METAANALYSIS; ANALGESIA; REMIFENTANIL; FENTANYL; RECOVERY;

D O I：

10.1016/j.bpa.2019.09.002

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Opioid-free anesthesia (OFA) is emerging as a new stimulating research perspective. The rationale to propose OFA is based on the aim to avoid the negative impact of intraoperative opioid on a patient's postoperative outcomes and also on the physiology of pathways involved in intraoperative nociception. It is based on the concept of multimodal anesthesia. OFA has been shown to be feasible but the literature is still scarce on the clinically meaningful benefits for patients as well as on the side effects and/or complications that might be associated with it. This review focused first on the physiology of nociception, the reasons for using or not using opioids during anesthesia, and then on the literature reporting evidence-based proofs of benefits/risks associated with OFA. (C) 2019 Published by Elsevier Ltd.

引用

页码：353 / 360

页数：8

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