Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

被引：12
|
作者：
Han, Junyan [1 ,2 ]
Lee, Tae Hoon [1 ]
Tung, Ching-Hsuan [1 ]
Lee, Daniel Y. [1 ,3 ]
机构：
[1] Weill Cornell Med Coll, Houston Methodist Res Inst, Dept Translat Imaging, Houston, TX 77030 USA
[2] Houston Methodist Hosp, Dept Neurosurg, Kenneth R Peak Brain & Pituirary Tumor Ctr, Houston, TX 77030 USA
[3] Houston Methodist Hosp, Dept Radiol, Houston, TX 77030 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 48期
关键词：
MULTIDRUG-RESISTANCE; DELIVERY; CANCER; DISEASES;
D O I：
10.1039/c4ob01981d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.
引用
收藏
页码：9793 / 9796
页数：4
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