Plasma-initiated graft polymerization as an immobilization platform for metal free Russian propolis ethanol extracts designed specifically for biomaterials

被引：9

作者：

Ambi, Ashwin ^{[1
]}

Vera, Carolina ^{[1
]}

Parikh, Nisharg ^{[1
]}

Perez, Naidel ^{[1
]}

Rojas, Anthony Lopez ^{[1
]}

Kumar, Sanket ^{[1
]}

Stradford, Christopher ^{[1
]}

Borbon, Katherine ^{[1
]}

Bryan, Julia ^{[1
]}

Traba, Christian ^{[1
]}

机构：

[1] St Peters Univ, Dept Chem, Jersey City, NJ 07306 USA

来源：

BIOFOULING | 2018年 / 34卷 / 05期

关键词：

Plasma; grafting; immobilization; propolis; infections; BRAZILIAN GREEN PROPOLIS; SURFACES; PREVENTION; BIOFILMS; BACTERIA;

D O I：

10.1080/08927014.2018.1471467

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The antibacterial and anti-biofilm activities of propolis have been intensively reported. However, the application of this folk remedy as a means to prevent biomedical implant contamination has yet to be completely evaluated. In response to the significant resistant and infectious attributes of biofilms, biomaterials engineered to possess specific chemical and physical properties were immobilized with metal free Russian propolis ethanol extracts (MFRPEE), a known antibacterial agent. The results obtained from this study begin to examine the application of MFRPEE as a novel alternative method for the prevention of medical and biomedical implant infections. When constructed under specific experimental conditions, immobilized biomaterials showed excellent stability when subjected to simulated body fluid and fetal bovine serum. The ability of immobilized biomaterials to specifically target pathogens (both Gram-positive and Gram-negative biofilm forming bacteria), while promoting tissue cell growth, renders these biomaterials as potential candidates for clinical applications.

引用

页码：557 / 568

页数：12

共 34 条

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