IKK connects autophagy to major stress pathways

被引：36

作者：

Criollo, Alfredo ^{[1
,2
,3
,4
]}

Senovilla, Laura ^{[1
,2
,3
]}

Authier, Helene ^{[5
]}

Maiuri, Maria Chiara ^{[1
,2
,3
,6
]}

Morselli, Eugenia ^{[1
,2
,3
]}

Vitale, Ilio ^{[1
,2
,3
]}

Kepp, Oliver ^{[1
,2
,3
]}

Tasdemir, Ezgi ^{[1
,2
,3
]}

Galluzzi, Lorenzo ^{[1
,2
,3
]}

Shen, Shensi ^{[1
,2
,3
]}

Tailler, Maximilien ^{[1
,2
,3
]}

Delahaye, Nicolas ^{[2
,3
,7
]}

Tesniere, Antoine ^{[1
,2
,3
]}

De Stefano, Daniela ^{[6
]}

Ben Younes, Amena ^{[1
,2
,3
]}

Harper, Francis ^{[8
]}

Pierron, Gerard ^{[8
]}

Lavandero, Sergio ^{[4
]}

Zitvogel, Laurence ^{[2
,3
,7
]}

Israel, Alain ^{[9
]}

Baud, Veronique ^{[5
]}

Kroemer, Guido ^{[1
,2
,3
]}

机构：

[1] INSERM, U848, Villejuif, France

[2] Inst Gustave Roussy, Villejuif, France

[3] Univ Paris 11, Villejuif, France

[4] Univ Chile, FONDAP Ctr CEMC, Fac Chem & Pharmaceut Sci Med, Santiago, Chile

[5] Univ Paris 05, CNRS, UMR 8104, Inst Cochin, Paris, France

[6] Univ Naples Federico 2, Dipartimento Farmacol Sperimentale, Naples, Italy

[7] INSERM, U805, Villejuif, France

[8] Inst Andre Lwoff, CNRS, FRE 2937, Villejuif, France

[9] Inst Pasteur, CNRS, URA 2582, Paris, France

来源：

AUTOPHAGY | 2010年 / 6卷 / 01期

关键词：

AMPK; JNK1; mTOR; nutrient deprivation; rapamycin;

D O I：

10.4161/auto.6.1.10818

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NF kappa B is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (I kappa B kinase) complex, which is critical for the stress-elicited activation of NF kappa B, is sufficient to promote autophagy independent of NF kappa B, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

引用

页码：189 / 191

页数：3