Broadly neutralizing antibodies against HIV-1 and concepts for application

被引：26

作者：

Gruell, Henning ^{[1
,2
]}

Schommers, Philipp ^{[1
,2
,3
]}

机构：

[1] Univ Cologne, Fac Med, Inst Virol, Lab Expt Immunol, D-50931 Cologne, Germany

[2] Univ Cologne, Univ Hosp Cologne, D-50931 Cologne, Germany

[3] Univ Cologne, Dept Internal Med 1, Fac Med, D-50931 Cologne, Germany

来源：

CURRENT OPINION IN VIROLOGY | 2022年 / 54卷

关键词：

SILENT FACE; THERAPY; RESPONSES;

D O I：

10.1016/j.coviro.2022.101211

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Potent broadly neutralizing antibodies (bNAbs) targeting HIV-1 exhibit significant antiviral activity in humans. Recent advances have demonstrated that novel antibodies and bNAb combinations can effectively restrict the development of viral escape mutations. Moreover, passive immunization trials have provided proof-of-principle for bNAb-mediated prevention of infection with antibody-sensitive HIV-1 strains. In contrast, clinical studies investigating the activity of HIV-1 bNAbs on the latent reservoir failed to demonstrate substantial effects. Clinical adoption of HIV-1 bNAbs will require the development of more potent and broadly active antibodies as well as their implementation in optimized strategies to fully harness the capabilities of bNAbs. We review preclinical and clinical studies on HIV-1 bNAbs to highlight their potential and remaining limitations.

引用

页数：8

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