Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis

被引：15
作者：
Song, Yu [1 ]
Wang, Huimin [1 ]
Huang, Hongli [1 ]
Zhu, Zhengyan [1 ]
机构：
[1] Third Hosp Wuhan, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
来源：
GYNECOLOGICAL ENDOCRINOLOGY | 2020年 / 36卷 / 03期
关键词：
N-acetyl-cysteine (NAC); metformin; polycystic ovary syndrome (PCOS); POLYCYSTIC-OVARY-SYNDROME; N-ACETYL-CYSTEINE; CLOMIPHENE CITRATE; OXIDATIVE STRESS; INSULIN SENSITIVITY; HOMOCYSTEINE LEVELS; WOMEN; ACETYLCYSTEINE; ANTIOXIDANT; ROSIGLITAZONE;
D O I：
10.1080/09513590.2019.1689553
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Our aim is to evaluate the clinical effectiveness and safety by comparing N-acetyl-cysteine (NAC) with metformin administrated by polycystic ovary syndrome (PCOS) patients. Systematic review and meta-analysis of randomized clinical trials (RCTs). MEDLINE, EMBASE, Web of Science and China National Knowledge Infrastructure were searched for studies. 10 studies were considered eligible for inclusion. NAC significantly reduced BMI and total testosterone, there was no significant difference in pregnancy rate, serum LH level, fasting insulin, and LH/FSH ratio. In conclusions, NAC may be considered as an alternative supplement to metformin, but large-scale randomized controlled trials are needed to assess the efficacy and safety of NAC in PCOS patients.
引用
收藏
页码：204 / 210
页数：7
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