High-throughput screening was performed to optimize the Cu/Mn ratio of Cu-Mn oxide catalyst for methanol synthesis from syngas at 1 MPa and 523 K. The autoclave equipped with twelve catalyst beds was connected to a conventional high-pressure gas flow apparatus. Identical temperature and identical space velocity over the 12 catalyst beds was ensured. The catalyst showed the same activity as that of the catalyst used in the conventional test, indicating the possibility of high efficiency catalyst screening under conventional testing conditions.