Epstein-Barr Virus-Associated Primary Central Nervous System Lymphoma in the Japanese Population

被引：21

作者：

Kitai, Ryuhei ^{[1
]}

Matsuda, Ken ^{[1
]}

Adachi, Erika ^{[1
]}

Saito, Yasushi ^{[1
]}

Nakajima, Tsuyoshi ^{[1
]}

Takeuchi, Hiroaki ^{[1
]}

Sato, Kazufumi ^{[1
]}

Imamura, Yoshiaki ^{[2
]}

Kubota, Toshihiko ^{[1
]}

机构：

[1] Univ Fukui, Fac Med Sci, Dept Neurosurg, Eiheiji, Fukui 9101193, Japan

[2] Univ Fukui Hosp, Div Surg Pathol, Fukui, Japan

来源：

NEUROLOGIA MEDICO-CHIRURGICA | 2010年 / 50卷 / 02期

关键词：

Epstein-Barr virus; Japan; immunocompromised patient; primary central nervous system lymphoma; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; NON-HODGKINS-LYMPHOMA; BRAIN LYMPHOMA; EBV INFECTION; IMMUNOCOMPETENT; HYBRIDIZATION; CHEMOTHERAPY; INDIVIDUALS; CARCINOMAS; EXPRESSION;

D O I：

10.2176/nmc.50.114

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The incidence of Epstein-Barr virus (EBV)-associated primary central nervous system (CNS) lymphoma in Japan was assessed using in situ hybridization of EBV-encoded small ribonucleic acid-1 (EBER-1) to identify the presence of EBV in 22 cases of formalin-fixed and paraffin-embedded primary CNS lymphoma. All cases were B-cell lymphoma. EBER-1 expression was observed in the nuclei of 3 of 22 primary CNS lymphoma cases (13.6%). The incidence of EBV-positive lymphoma in Japanese cases is higher than previously reported from Western countries. Patients with EBV-positive primary CNS lymphoma showed shorter survival than those with negative tumors (median 4 months vs. 26 months). EBER-1 in situ hybridization for the detection of EBV infection is rapid and reliable. Infrequent association suggests a different pathogenetic mechanism in the evolution of these tumors. Geographical differences in the incidence of EBV-associated primary CNS lymphoma may reflect epidemiological factors.

引用

页码：114 / 118

页数：5

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