The role of mitochondrial DNA mutations in mammalian aging

被引：139

作者：

Kujoth, Gregory C. ^{[1
]}

Bradshaw, Patrick C. ^{[1
]}

Haroon, Suraiya ^{[1
]}

Prolla, Tomas A. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Genet & Med Genet, Madison, WI 53706 USA

来源：

PLOS GENETICS | 2007年 / 3卷 / 02期

关键词：

D O I：

10.1371/journal.pgen.0030024

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mitochondrial genome instability. We also discuss potential mechanisms for the generation of these mutations and the means by which they may mediate their pathological consequences. Strategies for slowing the accumulation and attenuating the effects of mtDNA mutations are discussed.

引用

页码：161 / 173

页数：13

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