Utility of Measuring (1,3)-β-D-Glucan in Cerebrospinal Fluid for Diagnosis of Fungal Central Nervous System Infection

被引：42
|
作者：
Lyons, Jennifer L. [1 ,2 ]
Thakur, Kiran T. [3 ]
Lee, Rick [4 ]
Watkins, Tonya [5 ]
Pardo, Carlos A. [3 ]
Carson, Kathryn A. [6 ]
Markley, Barbara [7 ]
Finkelman, Malcolm A. [7 ]
Marr, Kieren A. [8 ,9 ]
Roos, Karen L. [10 ]
Zhang, Sean X. [4 ,5 ]
机构：
[1] Brigham & Womens Hosp, Dept Neurol, Div Neurol Infect, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA
[4] Johns Hopkins Univ Hosp, Microbiol Lab, Baltimore, MD 21287 USA
[5] Johns Hopkins Sch Med, Dept Pathol, Div Med Microbiol, Baltimore, MD USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[7] Associates Cape Cod Inc, Falmouth, MA USA
[8] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA
[9] Johns Hopkins Sch Med, Dept Oncol, Div Infect Dis, Baltimore, MD USA
[10] Indiana Univ, Indianapolis, IN 46204 USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2015年 / 53卷 / 01期
基金：
美国国家卫生研究院;
关键词：
BETA-D-GLUCAN; MULTISTATE OUTBREAK; PLASMA; ASSAY; (1-3)-BETA-D-GLUCAN; MENINGITIS; AID;
D O I：
10.1128/JCM.02301-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
(1-3)-beta-D-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.
引用
收藏
页码：319 / 322
页数：4
相关论文
共 50 条
  • [31] Role of (1→3)-β-D-glucan in the diagnosis of invasive aspergillosis
    Marty, Francisco M.
    Koo, Sophia
    MEDICAL MYCOLOGY, 2009, 47 : S233 - S240
  • [32] Lower sensitivity of serum (1,3)-β-D-glucan for the diagnosis of candidaemia due to Candida parapsilosis
    Mikulska, M.
    Giacobbe, D. R.
    Furfaro, E.
    Mesini, A.
    Marchese, A.
    Del Bono, V.
    Viscoli, C.
    CLINICAL MICROBIOLOGY AND INFECTION, 2016, 22 (07) : 646.e5 - 646.e8
  • [33] (1,3)-β-D-glucan assay for diagnosing invasive fungal infections in critically ill patients with hematological malignancies
    Azoulay, Elie
    Guigue, Nicolas
    Darmon, Michael
    Mokart, Djamel
    Lemiale, Virginie
    Kouatchet, Achille
    Mayaux, Julien
    Vincent, Francois
    Nyunga, Martine
    Bruneel, Fabrice
    Rabbat, Antoine
    Bretagne, Stephane
    Lebert, Christine
    Meert, Anne-Pascale
    Benoit, Dominique
    Pene, Frederic
    ONCOTARGET, 2016, 7 (16) : 21484 - 21495
  • [34] Utility of Serum 1,3-β-D-Glucan Testing for Diagnosis and Prognostication in COVID-19-Associated Pulmonary Aspergillosis
    Egger, Matthias
    Prueller, Florian
    Krause, Robert
    Prattes, Juergen
    Hoenigl, Martin
    MICROBIOLOGY SPECTRUM, 2022, 10 (03):
  • [35] (1→3)-β-D-glucan and galactomannan testing for the diagnosis of fungal peritonitis in peritoneal dialysis patients, a pilot study
    Worasilchai, Navaporn
    Leelahavanichkul, Asada
    Kanjanabuch, Talerngsak
    Thongbor, Nisa
    Lorvinitnun, Pichet
    Sukhontasing, Kanya
    Finkelman, Malcolm
    Chindamporn, Ariya
    MEDICAL MYCOLOGY, 2015, 53 (04) : 338 - 346
  • [36] Evaluation of a Novel Plasma (1,3)-β-D-Glucan Detection Assay for Diagnosis of Candidemia in Pediatric Patients
    Liu, Ying
    Chen, Feng
    Zhu, Xiaodong
    Shen, Lisong
    Zhang, Sean X.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (09) : 3017 - 3020
  • [37] Clinical Performance of the (1,3)-β-D-Glucan Assay in Early Diagnosis of Nosocomial Candida Bloodstream Infections
    Del Bono, Valerio
    Delfino, Emanuele
    Furfaro, Elisa
    Mikulska, Malgorzata
    Nicco, Elena
    Bruzzi, Paolo
    Mularoni, Alessandra
    Bassetti, Matteo
    Viscoli, Claudio
    CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (12) : 2113 - 2117
  • [38] (1,3) (β)-D-Glucan in Bronchoalveolar Lavage of Lung Transplant Recipients for the Diagnosis of Invasive Pulmonary Aspergillosis
    Bhaskaran, Archana
    Kabbani, Dima
    Singer, Lianne G.
    Prochnow, Taisa
    Bhimji, Alya
    Rotstein, Coleman
    Finkelman, Malcolm A.
    Keshavjee, Shaf
    Husain, Shahid
    MEDICAL MYCOLOGY, 2017, 55 (02) : 173 - 179
  • [39] Detection of (1→3)-β-D-Glucan as an Adjunct to Diagnosis in a Mixed Population with Uncommon Proven Invasive Fungal Diseases or with an Unusual Clinical Presentation
    Soledad Cuetara, Maria
    Alhambra, Almudena
    Dolores Moragues, Maria
    Gonzalez-Elorza, Ernesto
    Ponton, Jose
    del Palacio, Amalia
    CLINICAL AND VACCINE IMMUNOLOGY, 2009, 16 (03) : 423 - 426
  • [40] Diagnostic value of (1 → 3)-β-D-glucan in bronchoalveolar lavage fluid for invasive fungal disease: A meta-analysis
    Shi, Xin-yu
    Liu, Yao
    Gu, Xian-min
    Hao, Sheng-yu
    Wang, Yu-hong
    Yan, Di
    Jiang, Shu-juang
    RESPIRATORY MEDICINE, 2016, 117 : 48 - 53
12345