Utility of Measuring (1,3)-β-D-Glucan in Cerebrospinal Fluid for Diagnosis of Fungal Central Nervous System Infection

被引：42
|
作者：
Lyons, Jennifer L. [1 ,2 ]
Thakur, Kiran T. [3 ]
Lee, Rick [4 ]
Watkins, Tonya [5 ]
Pardo, Carlos A. [3 ]
Carson, Kathryn A. [6 ]
Markley, Barbara [7 ]
Finkelman, Malcolm A. [7 ]
Marr, Kieren A. [8 ,9 ]
Roos, Karen L. [10 ]
Zhang, Sean X. [4 ,5 ]
机构：
[1] Brigham & Womens Hosp, Dept Neurol, Div Neurol Infect, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA
[4] Johns Hopkins Univ Hosp, Microbiol Lab, Baltimore, MD 21287 USA
[5] Johns Hopkins Sch Med, Dept Pathol, Div Med Microbiol, Baltimore, MD USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[7] Associates Cape Cod Inc, Falmouth, MA USA
[8] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA
[9] Johns Hopkins Sch Med, Dept Oncol, Div Infect Dis, Baltimore, MD USA
[10] Indiana Univ, Indianapolis, IN 46204 USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2015年 / 53卷 / 01期
基金：
美国国家卫生研究院;
关键词：
BETA-D-GLUCAN; MULTISTATE OUTBREAK; PLASMA; ASSAY; (1-3)-BETA-D-GLUCAN; MENINGITIS; AID;
D O I：
10.1128/JCM.02301-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
(1-3)-beta-D-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.
引用
收藏
页码：319 / 322
页数：4
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