Evaluating Binuclear Copper(II) Complexes for Glycoside Hydrolysis

被引：34

作者：

Striegler, Susanne ^{[1
]}

Dunaway, Natasha A. ^{[1
]}

Gichinga, Moses G. ^{[1
]}

Barnett, James D. ^{[1
]}

Nelson, Anna-Gay D. ^{[1
]}

机构：

[1] Auburn Univ, Dept Chem & Biochem, Auburn, AL 36849 USA

来源：

INORGANIC CHEMISTRY | 2010年 / 49卷 / 06期

基金：

美国国家科学基金会;

关键词：

METAL-COMPLEXES; PHOSPHODIESTER HYDROLYSIS; CYCLODEXTRIN DERIVATIVES; ARTIFICIAL GLYCOSIDASES; MAGNETIC-INTERACTIONS; MOLECULAR-STRUCTURE; DINUCLEAR; EFFICIENT; CLEAVAGE; CATALYST;

D O I：

10.1021/ic9014064

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three binuclear copper(II) complexes were characterized as solids by X-ray diffraction and in solution by UV/vis spectrophotometric titration, and subsequently evaluated for their glycosidase-like activity. The structure analysis revealed comparable intermetallic Cu center dot center dot center dot Cu distances (similar to 3.5 angstrom) for the complexes 2 and 3. Despite this similarity, the composition of the complexes differs significantly in aqueous solution as revealed by spectrophotometric titrations. The hydrolysis of selected nitrophenylglycopyranosides is up to 11,000-fold accelerated over background in the presence of the copper(II) complexes in 3-(cyclohexylamino)-1-propanesulfonic acid (CAPS) buffer at pH 10.5 and 30 degrees C.

引用

页码：2639 / 2648

页数：10

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