3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy

被引：23

作者：

Sharifi, Majid ^{[1
,2
,3
]}

Bai, Qian ^{[1
]}

Babadaei, Mohammad Mahdi Nejadi ^{[4
]}

Chowdhury, Farhan ^{[5
]}

Hassan, Mahbub ^{[6
]}

Taghizadeh, Akbar ^{[3
]}

Derakhshankhah, Hossein ^{[7
]}

Khan, Suliman ^{[1
]}

Hasan, Anwarul ^{[8
,9
]}

Falahati, Mojtaba ^{[10
]}

机构：

[1] Zhengzhou Univ, Dept Anesthesiol, Affiliated Hosp 2, Zhengzhou, Peoples R China

[2] Shahroud Univ Med Sci, Sch Med, Dept Tissue Engn, Shahroud, Iran

[3] Univ Tabriz, Fac Agr, Dept Anim Sci, Tabriz, Iran

[4] Islamic Azad Univ, Fac Biol Sci, Dept Mol Genet, North Tehran Branch, Tehran, Iran

[5] Southern Illinois Univ Carbondale, Dept Mech Engn & Energy Proc, Carbondale, IL 62901 USA

[6] Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia

[7] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah 6714415153, Iran

[8] Qatar Univ, Dept Mech & Ind Engn, Coll Engn, Doha 2713, Qatar

[9] Qatar Univ, Biomed Res Ctr, Doha 2713, Qatar

[10] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Nanotechnol, Tehran Med Sci, Tehran, Iran

来源：

JOURNAL OF CONTROLLED RELEASE | 2021年 / 333卷 / 333期

基金：

中国博士后科学基金;

关键词：

3D bioprinting; Breast cancer; Stromal components; Tumor models; Polymeric and composite scaffolds; Drug screening; TUMOR MICROENVIRONMENT; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; TISSUE STIFFNESS; CULTURE MODELS; LYSYL OXIDASE; CELL-CULTURE; SCAFFOLDS; BONE; DRUG;

D O I：

10.1016/j.jconrel.2021.03.026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bioprinting technique with specialized tissue production allows the study of biological, physiological, and behavioral changes of cancerous and non-cancerous tissues in response to pharmacological compounds in personalized medicine. To this end, to evaluate the efficacy of anticancer drugs before entering the clinical setting, tissue engineered 3D scaffolds containing breast cancer and derived from the especially patient, similar to the original tissue architecture, can potentially be used. Despite recent advances in the manufacturing of 3D bioprinted breast cancer tissue (BCT), many studies still suffer from reproducibility primarily because of the uncertainty of the materials used in the scaffolds and lack of printing methods. In this review, we present an overview of the breast cancer environment to optimize personalized treatment by examining and identifying the physiological and biological factors that mimic BCT. We also surveyed the materials and techniques related to 3D bioprinting, i.e, 3D bioprinting systems, current strategies for fabrication of 3D bioprinting tissues, cell adhesion and migration in 3D bioprinted BCT, and 3D bioprinted breast cancer metastasis models. Finally, we emphasized on the prospective future applications of 3D bioprinted cancer models for rapid and accurate drug screening in breast cancer.

引用

页码：91 / 106

页数：16

共 140 条

[71] A new microrheometric approach reveals individual and cooperative roles for TGF-β1 and IL-1β in fibroblast-mediated stiffening of collagen gels [J].