Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression

被引：135

作者：

Mihailovich, Marija ^{[1
]}

Militti, Cristina ^{[1
]}

Gabaldon, Toni ^{[2
]}

Gebauer, Fatima ^{[1
]}

机构：

[1] Ctr Regulacio Genom CRG UPF, Gene Regulat Programme, Barcelona 08003, Spain

[2] Ctr Regulacio Genom CRG UPF, Bioinformat Programme, Barcelona 08003, Spain

来源：

BIOESSAYS | 2010年 / 32卷 / 02期

关键词：

CSD; exosome; Lin-28; S1; translation initiation factor; UNR; YB-1; RNA-BINDING PROTEIN; RIBOSOME ENTRY SEGMENT; NUCLEIC-ACID-BINDING; MSL-2; MESSENGER-RNA; Y-BOX PROTEINS; N-RAS; SEX-LETHAL; TRANSLATIONAL REPRESSION; INTERNAL INITIATION; DOSAGE COMPENSATION;

D O I：

10.1002/bies.200900122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient P-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.

引用

页码：109 / 118

页数：10

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