Genome-wide scan for body composition in pigs reveals important role of imprinting

被引：215

作者：

de Koning, DJ ^{[1
]}

Rattink, AP ^{[1
]}

Harlizius, B ^{[1
]}

van Arendonk, JAM ^{[1
]}

Brascamp, EW ^{[1
]}

Groenen, MAM ^{[1
]}

机构：

[1] Wageningen Univ, Wageningen Inst Anim Sci, Anim Breeding & Genet Grp, NL-6700 AH Wageningen, Netherlands

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 14期

关键词：

D O I：

10.1073/pnas.140216397

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of imprinting in body composition was investigated in an experimental cross between Chinese Meishan pigs and commercial Dutch pigs. A whole-genome scan revealed significant evidence for five quantitative trait loci (QTL) affecting body composition, of which four were imprinted. Imprinting was tested with a statistical model that separated the expression of paternally and maternally inherited alleles, For back fat thickness, a paternally expressed QTL was found on Sus scrofa chromosome 2 (SSC2), and a Mendelian-expressed QTL was found on SSC7, In the same region of SSC7, a maternally expressed QTL affecting muscle depth was found. Chromosome 6 harbored a maternally expressed QTL on the short arm and a paternally expressed QTL on the long arm, both affecting intramuscular fat content, The individual QTL explained from 2% up to 10% of the phenotypic variance. The known homologies to human and mouse did not reveal positional candidate genes. This study demonstrates that testing for imprinting should become a standard procedure to unravel the genetic control of multifactorial traits.

引用

页码：7947 / 7950

页数：4

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