Prediction of thrombus formation using vortical structures presentation in Stanford type B aortic dissection: A preliminary study using CFD approach

被引:46
作者
Ab Naim, Wan Naimah Wan [1 ]
Ganesan, Poo Balan [2 ]
Sun, Zhonghua [3 ]
Liew, Yih Miin [1 ]
Qian, Yi [4 ]
Lee, Chang-Joon [4 ]
Jansen, Shirley [5 ,6 ]
Hashim, Shahrul Amry [7 ]
Lim, Einly [1 ]
机构
[1] Univ Malaya, Dept Biomed Engn, Fac Engn, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Dept Mech Engn, Fac Engn, Kuala Lumpur 50603, Malaysia
[3] Curtin Univ, Dept Med Radiat Sci, Perth, WA 6845, Australia
[4] Macquarie Univ, Australian Sch Adv Med, 2 Technol Pl, N Ryde, NSW 2109, Australia
[5] Sir Charles Gairdner Hosp, Dept Vasc Surg, Nedlands, WA 6009, Australia
[6] Curtin Univ, Sch Populat Hlth, Perth, WA 6845, Australia
[7] Univ Malaya, Fac Med Bldg, Dept Surg, Kuala Lumpur 50603, Malaysia
关键词
Stanford type B aortic dissection; Vortical structures; Thrombus; Computational fluid dynamics; False lumen; Hemodynamics; COMPUTATIONAL FLUID-DYNAMICS; FALSE LUMEN; BLOOD-FLOW; NUMERICAL-SIMULATION; STEADY FLOW; TEAR SIZE; HEMODYNAMICS; ARTERIES; MODELS; VIVO;
D O I
10.1016/j.apm.2015.09.096
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
False lumen patency has been recognized as the key determinant of aneurismal dilatation and rupture, whereas complete thrombosis has been proven clinically to improve disease outcomes. However, to date, there is no definitive method that could predict false lumen thrombosis in Stanford type B aortic dissection patient. The present study aims to use the evolution of vortical structures throughout a cardiac cycle and its interaction with the wall shear stress (WSS) to illustrate the potential mechanism behind the formation of thrombus and predict its highly possible location in an aortic dissection patient. A three-dimensional (3D) patient specific Stanford type B aortic dissection domain was generated from computed tomography (CT) angiographic images. The effects of false lumen size on vortical structures and the subsequent risk of thrombus formation were investigated. The Carreau-Yasuda model, representing non-Newtonian fluid property was used to study the difference between Newtonian and non Newtonian fluid settings on vortical structures. Based on our analysis, we predicted that the formation and thickening of thrombus is very much likely to occur at the posterior false lumen wall, distal to the entry tear region, in the patient. Higher lambda(2) intensity, associated with a higher maximum WSS and a lower minimum WSS, was achieved with an increase in the false lumen size, and we believed that this increases the risk of thrombus formation and thus aneurismal dilatation. On the other hand, percentage of flow entering the false lumen increased with an increase in the false lumen size, leading to a downward shift of the areas of thrombus formation along the false lumen wall. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:3115 / 3127
页数:13
相关论文
共 35 条
[1]  
Biasetti J., 2013, PHYS BLOOD FLOW ARTE, P43
[2]   Blood flow and coherent vortices in the normal and aneurysmatic aortas: a fluid dynamical approach to intraluminal thrombus formation [J].
Biasetti, Jacopo ;
Hussain, Fazle ;
Gasser, T. Christian .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2011, 8 (63) :1449-1461
[3]   Vortex shedding in steady flow through a model of an arterial stenosis and its relevance to mural platelet deposition [J].
Bluestein, D ;
Gutierrez, C ;
Londono, M ;
Schoephoerster, RT .
ANNALS OF BIOMEDICAL ENGINEERING, 1999, 27 (06) :763-773
[4]   Phase-Contrast Magnetic Resonance Imaging Measurements in Intracranial Aneurysms In Vivo of Flow Patterns, Velocity Fields, and Wall Shear Stress: Comparison with Computational Fluid Dynamics [J].
Boussel, Loic ;
Rayz, Vitaliy ;
Martin, Alastair ;
Acevedo-Bolton, Gabriel ;
Lawton, Michael T. ;
Higashida, Randall ;
Smith, Wade S. ;
Young, William L. ;
Saloner, David .
MAGNETIC RESONANCE IN MEDICINE, 2009, 61 (02) :409-417
[5]   The role of false lumen size in prediction of in-hospital complications after acute type B aortic dissection [J].
Chang, Chih-Ping ;
Liu, Juhn-Cherng ;
Liou, Ying-Ming ;
Chang, Shih-Sheng ;
Chen, Jan-Yow .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (14) :1170-1176
[6]   A patient-specific study of type-B aortic dissection: evaluation of true-false lumen blood exchange [J].
Chen, Duanduan ;
Mueller-Eschner, Matthias ;
von Tengg-Kobligk, Hendrik ;
Barber, David ;
Boeckler, Dittmar ;
Hose, Rod ;
Ventikos, Yiannis .
BIOMEDICAL ENGINEERING ONLINE, 2013, 12
[7]   A longitudinal study of Type-B aortic dissection and endovascular repair scenarios: Computational analyses [J].
Chen, Duanduan ;
Mueller-Eschner, Matthias ;
Kotelis, Drosos ;
Boeckler, Dittmar ;
Ventikos, Yiannis ;
von Tengg-Kobligk, Hendrik .
MEDICAL ENGINEERING & PHYSICS, 2013, 35 (09) :1321-1330
[8]   Analysis of Flow Patterns in a Patient-Specific Aortic Dissection Model [J].
Cheng, Z. ;
Tan, F. P. P. ;
Riga, C. V. ;
Bicknell, C. D. ;
Hamady, M. S. ;
Gibbs, R. G. J. ;
Wood, N. B. ;
Xu, X. Y. .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2010, 132 (05)
[9]   Initial findings and potential applicability of computational simulation of the aorta in acute type B dissection [J].
Cheng, Zhuo ;
Riga, Celia ;
Chan, Joyce ;
Hamady, Mohammad ;
Wood, Nigel B. ;
Cheshire, Nicholas J. W. ;
Xu, Yun ;
Gibbs, Richard G. J. .
JOURNAL OF VASCULAR SURGERY, 2013, 57 :35S-43S
[10]   Dynamics of blood flow and platelet transport in pathological vessels [J].
Einav, S ;
Bluestein, D .
CARDIAC ENGINEERING: FROM GENES AND CELLS TO STRUCTURE AND FUNCTION, 2004, 1015 :351-366