Immuno-metabolism and adipose tissue: The key role of hematopoietic stem cells

被引：15
作者：
Cousin, B. [1 ,2 ,3 ,4 ]
Casteilla, L. [1 ,2 ,3 ,4 ]
Laharrague, P. [1 ,2 ,3 ,4 ,5 ]
Luche, E. [1 ,2 ,3 ,4 ]
Lorsignol, A. [1 ,2 ,3 ,4 ]
Cuminetti, V. [1 ,2 ,3 ,4 ]
Paupert, J. [1 ,2 ,3 ,4 ]
机构：
[1] CNRS 5273, UMR STROMALab, F-31432 Toulouse 4, France
[2] Univ Toulouse 3, UPS, F-31432 Toulouse 4, France
[3] INSERM U1031, F-31432 Toulouse 4, France
[4] EFS Pyrenees Mediterranee, BP 84225, F-31432 Toulouse 4, France
[5] Hematol Lab, TSA 50032, F-31059 Toulouse, France
来源：
BIOCHIMIE | 2016年 / 124卷
关键词：
Adipose tissue; Hematopoietic stem cell; Metabolism; Obesity; Diabetes; Bone marrow; BONE-MARROW-TRANSPLANTATION; INSULIN-RESISTANCE; NOD MICE; PROGENITOR CELLS; STROMAL CELLS; T-CELLS; PROMOTES MYELOPOIESIS; IN-VITRO; OBESITY; LEPTIN;
D O I：
10.1016/j.biochi.2015.06.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The field of immunometabolism has come a long way in the past decade, leading to the emergence of a new role for white adipose tissue (WAT) that is now recognized to stand at the junction of immune and metabolic regulations. Interestingly, a crucial role of the abundant and heterogeneous immune population present in WAT has been proposed in the induction and development of metabolic diseases. Although a large body of data focused on mature immune cells, only few scattered studies are dedicated to leukocyte production, and the activity of hematopoietic stem cells (HSC) in these pathological states. Considering that blood cell production and the differentiation of HSCs and their progeny is orchestrated, in part, by complex interacting signals emanating from their microenvironment, it thus seems worth to better understand the relationships between metabolism and HSC. This review discusses the alterations of hematopoietic process described in metabolic diseases and focused on the emerging data concerning HSC present in WAT. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码：21 / 26
页数：6
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