C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media

被引：13

作者：

Yao, William ^{[1
,2
,3
]}

Frie, Meredith ^{[1
,2
,3
]}

Pan, Jeffrey ^{[1
,2
,3
]}

Pak, Kwang ^{[2
,3
,4
]}

Webster, Nicholas ^{[5
,6
]}

Wasserman, Stephen I. ^{[7
,8
]}

Ryan, Allen F. ^{[2
,3
,4
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Surg, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Otolaryngol, La Jolla, CA 92093 USA

[4] Vet Adm Med Ctr, Res Serv, San Diego, CA 92151 USA

[5] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Dept Endocrinol & Metab, La Jolla, CA 92093 USA

[7] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Dept Allergy & Immunol, La Jolla, CA 92093 USA

来源：

BMC IMMUNOLOGY | 2014年 / 15卷

基金：

美国国家卫生研究院;

关键词：

Middle ear; Nontypeable haemophilus influenzae; Infection; MAP kinase signaling; Tissue proliferation; Inflammation; ACTIVATED PROTEIN-KINASE; MIDDLE-EAR MUCOSA; IMMUNE-SYSTEM; AP-1; EXPRESSION; APOPTOSIS; CELLS; TRANSCRIPTION; RECOGNITION; PHOSPHATASE;

D O I：

10.1186/s12865-014-0046-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Innate immunity and tissue proliferation play important roles in otitis media (OM), the most common disease of childhood. CJUN terminal kinase (JNK) is potentially involved in both processes. Results: Genes involved in both innate immune and growth factor activation of JNK are upregulated during OM, while expression of both positive and negative JNK regulatory genes is altered. When compared to wildtypes (WTs), C57BL/6 mice deficient in JNK1 exhibit enhanced mucosal thickening, with delayed recovery, enhanced neutrophil recruitment early in OM, and delayed bacterial clearance. In contrast, JNK2(-/-) mice exhibit delayed mucosal hyperplasia that eventually exceeds that of WTs and is slow to recover, delayed recruitment of neutrophils, and failure of bacterial clearance. Conclusions: The results suggest that JNK1 and JNK2 play primarily opposing roles in mucosal hyperplasia and neutrophil recruitment early in OM. However, both isoforms are required for the normal resolution of middle ear infection.

引用

页数：10