Purpurinimides as photosensitizers: Effect of the presence and position of the substituents in the in vivo photodynamic efficacy

被引：53

作者：

Rungta, A

Zheng, G

Missert, JR

Potter, WR

Dougherty, TJ

Pandey, RK ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Photodynam Therapy Ctr, Buffalo, NY 14263 USA

[2] Roswell Pk Canc Inst, Dept Nucl Med, Buffalo, NY 14263 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(00)00274-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1463 / 1466

页数：4

共 11 条

[1]

Henderson BW, 1997, CANCER RES, V57, P4000

[2]

KOZYREV AN, 1997, TETRAHEDRON LETT, V38, P33356

[3]

Pandey R.K., 2000, PORPHYRIN HDB, V6

[4] CHLORIN AND PORPHYRIN DERIVATIVES AS POTENTIAL PHOTOSENSITIZERS IN PHOTODYNAMIC THERAPY [J].