Central roles of NLRs and inflammasomes in viral infection

被引：331

作者：

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 10期

关键词：

WEST-NILE-VIRUS; NF-KAPPA-B; INNATE IMMUNE-RESPONSES; TUMOR-NECROSIS-FACTOR; FAMILY-MEMBER NLRC5; DOUBLE-STRANDED-RNA; RIG-I; INFLUENZA-VIRUS; HOST-DEFENSE; NUCLEOTIDE-BINDING;

D O I：

10.1038/nri2851

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune response to viral infections is determined by a complex interplay between the pathogen and the host. Innate immune cells express a set of cytosolic sensors to detect viral infection. Recognition by these sensors induces the production of type I interferons and the assembly of inflammasome complexes that activate caspase-1, leading to production of interleukin-1 beta ( IL-1 beta) and IL-18. Here, I discuss recent progress in our understanding of the central roles of NOD-like receptors (NLRs) and inflammasomes in the immune response during viral infections. This information will improve our understanding of host defence mechanisms against viruses and provide new avenues for interfering in the pathogenesis of infectious diseases.

引用

页码：688 / 698

页数：11

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