Enhanced transdermal delivery of an anti-HIV agent via ethanolic liposomes
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Dubey, Vaibhav
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India
Dubey, Vaibhav
[1
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Mishra, Dinesh
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India
Mishra, Dinesh
[1
]
Nahar, Manoj
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India
Nahar, Manoj
[1
]
Jain, Vikas
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India
Jain, Vikas
[1
]
Jain, Narendra Kumar
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India
Jain, Narendra Kumar
[1
]
机构:
[1] Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar, Madhya Pradesh, India
Indinavir, as a protease inhibitor with a short biological half life, variable pH-dependent oral absorption, and extensive first-pass metabolism, presents a challenge with respect to its oral administration. The current work aims to formulate and characterize indinavir-bearing ethanolic liposomes (ethosomes), and to investigate their enhanced transdermal delivery potential. The prepared ethanolic liposomes were characterized to be spherical, unilamellar structures having low polydispersity, nanometric size range, and improved entrapment efficiency over other delivery formulations. Permeation studies of indinavir across human cadaver skin resulted in enhanced transdermal flux from ethanolic liposomes that was significantly (P < 0.05) greater than that with ethanolic drug solution, conventional liposomes, or plain drug solution. Additionally, the ethanolic liposomes showed the shortest lag time for indinavir, thus presenting a suitable approach for transdermal delivery of this protease inhibitor. From the Clinical Editor: This study characterizes indinavir bearing ethanolic liposomes (ethosomes), and investigate their enhanced transdermal delivery potential, demonstrating a potentially a suitable approach for transdermal delivery of this protease inhibitor for HIV treatment, which typically has been associated with limited bioavailability via the oral route. (C) 2010 Elsevier Inc. All rights reserved.
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Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, IndiaDr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, India
Dubey, Vaibhav
Mishra, Dinesh
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机构:Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, India
Mishra, Dinesh
Dutta, Tathagata
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机构:Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, India
Dutta, Tathagata
Nahar, Manoj
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机构:Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, India
Nahar, Manoj
Saraf, D. K.
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机构:Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, India
Saraf, D. K.
Jain, N. K.
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机构:Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Labs, Sagar 470003, India
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar 470003, MP, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar 470003, MP, India
Dubey, VaIbhav
Mishra, Dinesh
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar 470003, MP, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar 470003, MP, India
Mishra, Dinesh
Jain, N. K.
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Dr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar 470003, MP, IndiaDr Hari Singh Gour Vishwavidyalaya, Pharmaceut Res Lab, Dept Pharmaceut Sci, Sagar 470003, MP, India
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Reliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, IndiaReliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, India
Mundargi, Raghavendra C.
Babu, V. Ramesh
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Reliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, IndiaReliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, India
Babu, V. Ramesh
Rangaswamy, Vidhya
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Reliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, IndiaReliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, India
Rangaswamy, Vidhya
Aminabhavi, Tejraj M.
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Reliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, IndiaReliance Life Sci Pvt Ltd, Ind Biotechnol Grp, Dhirubhai Ambani Life Sci Ctr, Navi Mumbai 400701, India
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Tabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz 5166414766, Iran
Tabriz Univ Med Sci, Fac Pharm, Dept Pharmaceut, Tabriz 5166414766, Iran
Tabriz Univ Med Sci, Fac Pharm, Student Res Comm, Tabriz 5166414766, IranTabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz 5166414766, Iran
Ghanbarzadeh, Saeed
Arami, Sanam
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Tabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz 5166414766, Iran
Tabriz Univ Med Sci, Fac Pharm, Student Res Comm, Tabriz 5166414766, Iran
Tabriz Univ Med Sci, Fac Pharm, Dept Pharmaceut Biotechnol, Tabriz 5166414766, IranTabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz 5166414766, Iran