Current Perspectives on HIV-1 Antiretroviral Drug Resistance

被引：126

作者：

Iyidogan, Pinar ^{[1
]}

Anderson, Karen S. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA

来源：

VIRUSES-BASEL | 2014年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HIV-1; antiviral therapy; drug resistance; evolution; lethal mutagenesis; resistance monitoring; IMMUNODEFICIENCY-VIRUS TYPE-1; NONNUCLEOSIDE REVERSE-TRANSCRIPTASE; AMINO-ACID SUBSTITUTIONS; EXPERIENCED HIV-1-INFECTED PATIENTS; DEPENDENT PRIMER UNBLOCKING; SMALL-MOLECULE INHIBITOR; CLEAVAGE SITE MUTATIONS; RNA-POLYMERASE-II; DYNAMICS IN-VIVO; LETHAL MUTAGENESIS;

D O I：

10.3390/v6104095

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a chronic and manageable disease. However, treatment is only effective until HIV-1 develops resistance against the administered drugs. The most recent antiretroviral drugs have become superior at delaying the evolution of acquired drug resistance. In this review, the viral fitness and its correlation to HIV-1 mutation rates and drug resistance are discussed while emphasizing the concept of lethal mutagenesis as an alternative therapy. The development of resistance to the different classes of approved drugs and the importance of monitoring antiretroviral drug resistance are also summarized briefly.

引用

页码：4095 / 4139

页数：45

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