Lignans from Trachelospermum jasminoides and Synergistic Antifungal Activity

被引：0
|
作者：
Guo, Liang-Jun [1 ,2 ]
Xu, Li-Ping [1 ,2 ]
Zheng, Wei [1 ,2 ]
Dong, Jia-Xiao [1 ,2 ,3 ]
Yi, Xian-Hui [4 ]
Jin, Yong-Sheng [3 ]
机构：
[1] Anhui Med Univ, PLA Clin Coll 98, Hosp PLA 98, Dept Pharm, Huzhou 313000, Zhejiang, Peoples R China
[2] Anhui Med Univ, PLA Clin Coll 98, Hosp PLA 98, Dept Pharm, Hefei 230032, Anhui, Peoples R China
[3] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
[4] Liwah Pharmaceut Co Ltd, Zhenhai Branch, Ningbo 315200, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 06期
关键词：
antifungal activity; lignans; synergy; Trachelospermum jasminoides; CANDIDA-ALBICANS RESISTANT; IN-VITRO SYNERGISM; CHEMICAL-CONSTITUENTS; FLUCONAZOLE; BAICALEIN; PLANTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The vines of Trachelospermum jasminoides (Lindl.) Lem. is used in folk medicine as aching of the waist and knee and traumatic injuries. This study isolated the lignans of leaves and stems and evaluated for their synergistic antifungal activity with fluconazole against fluconazole-resistant Candida albicans 103 in vitro. Seven lignans were isolated from the leaves and stems of T. jasminoides. The dimethylmatairesinol (7) was isolated from this genus for the first time. The results of synergistic antifungal activity with fluconazole against C. albicans 103 showed that all compounds except 2 and 7 exhibited good synergy in combination with fluconazole. Of these active compounds, 1, 5 and 6 (FICI = 0.125) showed more potent synergistic antifungal effects than baicalein (FICI = 0.188).
引用
收藏
页码：1236 / 1240
页数：5
相关论文
共 50 条
  • [41] Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts
    Soberon, Jose R.
    Sgariglia, Melina A.
    Torrez, Jose A. Carabajal
    Aguilar, Franco A.
    Pero, Edgardo J., I
    Sampietro, Diego A.
    de Luco, Julia Fernandez
    Labadie, Guillermo R.
    HELIYON, 2020, 6 (10)
  • [42] Antifungal Activity of CHE-23C, a Dimeric Sesquiterpene from Chloranthus henryi
    Lee, Yun Mi
    Moon, Jae Sun
    Yun, Bong-Sik
    Park, Ki Duk
    Choi, Gyung Ja
    Kim, Jin-Cheol
    Lee, Sang Han
    Kim, Sung Uk
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (13) : 5750 - 5755
  • [43] The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans
    Wang, Yuan-Hua
    Dong, Huai-Huai
    Zhao, Fei
    Wang, Jie
    Yan, Fang
    Jiang, Yuan-Ying
    Jin, Yong-Sheng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (13) : 3098 - 3102
  • [44] Synergistic antifungal activity of combinations of Artemisia annua extract with fluconazole against resistant strains of Candida albicans
    Ngwu, Maria, I
    Ngwu, Godwin, I
    Okorie, Chibundo N.
    Emencheta, Stephen C.
    Odimegwu, Damian C.
    Attama, Anthony A.
    Ibezim, Emmanuel C.
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2024, 23 (06) : 941 - 949
  • [45] Four Lignans from Syringa pinnatifolia and Their Antioxidant Activity
    Qing-hu Wang
    Xiu-lan Wang
    Bai-yinmu-qi-er Bao
    Jing-jing Han
    Wu-li-ji Ao
    Chemistry of Natural Compounds, 2018, 54 : 18 - 21
  • [46] Antiplasmodial Activity of Lignans and Extracts from Pycnanthus angolensis
    Abrantes, Marta
    Mill-Homens, Tania
    Duarte, Noelia
    Lopes, Dinora
    Cravo, Pedro
    Madureira, Maria do Ceu
    Ferreira, Maria-Jose U.
    PLANTA MEDICA, 2008, 74 (11) : 1408 - 1412
  • [47] New lignans with neuroprotective activity from Adelostemma gracillimum
    Zhang, Jun
    Guo, Shengjun
    Chan, Kim W.
    Tong, Estella P. S.
    Fu, Guangmiao
    Mu, Quanzhang
    Ip, Fanny C. F.
    Ip, Nancy Y.
    PHYTOCHEMISTRY LETTERS, 2016, 16 : 1 - 7
  • [48] Four Lignans from Syringa pinnatifolia and Their Antioxidant Activity
    Wang, Qing-hu
    Wang, Xiu-lan
    Bao, Bai-yinmu-qi-er
    Han, Jing-jing
    Ao, Wu-li-ji
    CHEMISTRY OF NATURAL COMPOUNDS, 2018, 54 (01) : 18 - 21
  • [49] Characterization of graphislactone a as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp 1FB-E001, an endophytic fungus in Trachelospermum jasminoides
    Song, YC
    Huang, WY
    Sun, C
    Wang, FW
    Tan, RX
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (03) : 506 - 509
  • [50] Synergistic Antifungal Activity of Phellodendri Cortex and Magnoliae Cortex against Candida albicans
    Na H.
    Kim T.-J.
    Journal of the Korean Wood Science and Technology, 2022, 50 (01): : 12 - 30
12345