Lignans from Trachelospermum jasminoides and Synergistic Antifungal Activity

被引：0
|
作者：
Guo, Liang-Jun [1 ,2 ]
Xu, Li-Ping [1 ,2 ]
Zheng, Wei [1 ,2 ]
Dong, Jia-Xiao [1 ,2 ,3 ]
Yi, Xian-Hui [4 ]
Jin, Yong-Sheng [3 ]
机构：
[1] Anhui Med Univ, PLA Clin Coll 98, Hosp PLA 98, Dept Pharm, Huzhou 313000, Zhejiang, Peoples R China
[2] Anhui Med Univ, PLA Clin Coll 98, Hosp PLA 98, Dept Pharm, Hefei 230032, Anhui, Peoples R China
[3] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
[4] Liwah Pharmaceut Co Ltd, Zhenhai Branch, Ningbo 315200, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 06期
关键词：
antifungal activity; lignans; synergy; Trachelospermum jasminoides; CANDIDA-ALBICANS RESISTANT; IN-VITRO SYNERGISM; CHEMICAL-CONSTITUENTS; FLUCONAZOLE; BAICALEIN; PLANTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The vines of Trachelospermum jasminoides (Lindl.) Lem. is used in folk medicine as aching of the waist and knee and traumatic injuries. This study isolated the lignans of leaves and stems and evaluated for their synergistic antifungal activity with fluconazole against fluconazole-resistant Candida albicans 103 in vitro. Seven lignans were isolated from the leaves and stems of T. jasminoides. The dimethylmatairesinol (7) was isolated from this genus for the first time. The results of synergistic antifungal activity with fluconazole against C. albicans 103 showed that all compounds except 2 and 7 exhibited good synergy in combination with fluconazole. Of these active compounds, 1, 5 and 6 (FICI = 0.125) showed more potent synergistic antifungal effects than baicalein (FICI = 0.188).
引用
收藏
页码：1236 / 1240
页数：5
相关论文
共 50 条
  • [31] Synergistic antifungal activity of the lipophilic fraction of Hypericum carinatum and fluconazole
    Gabriela C. Meirelles
    Bruna Pippi
    Camila Hatwig
    Francisco M. C. de Barros
    Luis F. S. de Oliveira
    Gilsane L. von Poser
    Alexandre M. Fuentefria
    Revista Brasileira de Farmacognosia, 2017, 27 : 118 - 123
  • [32] Synergistic antifungal activity of pyrazole thio-oxadiazole derivatives
    Patil, Amar
    Jadhav, Rahul
    Raundal, Hemant
    Bobade, Vivek
    Sharma, Lokesh
    Badgujar, Rupali
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2015, 54 (09): : 1128 - 1133
  • [33] Potential antifungal applications of heterometallic silica nanohybrids: A synergistic activity
    Yapa, Piumika
    Munaweera, Imalka
    Weerasekera, Manjula M.
    Weerasinghe, Laksiri
    Sandaruwan, Chanaka
    BIOMATERIALS ADVANCES, 2024, 162
  • [34] Synergistic antifungal activity of the lipophilic fraction of Hypericum carinatum and fluconazole
    Meirelles, Gabriela C.
    Pippi, Bruna
    Hatwig, Camila
    de Barros, Francisco M. C.
    de Oliveira, Luis F. S.
    von Poser, Gilsane L.
    Fuentefria, Alexandre M.
    REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2017, 27 (01): : 118 - 123
  • [35] Analgesic activity of the lignans from Lychnophora ericoides
    Borsato, MLC
    Grael, CFF
    Souza, GEP
    Lopes, NP
    PHYTOCHEMISTRY, 2000, 55 (07) : 809 - 813
  • [36] Cytotoxic activity of lignans from Hibiscus cannabinus
    Moujir, Laila
    Seca, Ana M. L.
    Silva, Artur M. S.
    Lopez, Manuel R.
    Padilla, Nayely
    Cavaleiro, Jose A. S.
    Neto, Carlos P.
    FITOTERAPIA, 2007, 78 (05) : 385 - 387
  • [37] Anti-inflammatory effects of β-sitosterol-β-D-glucoside from Trachelospermum jasminoides (Apocynaceae) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages
    Choi, Ji Na
    Choi, Yun-Hyeok
    Lee, Jeong-Min
    Noh, Ill Chan
    Park, Jae Won
    Choi, Wahn Soo
    Choi, Jung Ho
    NATURAL PRODUCT RESEARCH, 2012, 26 (24) : 2340 - 2343
  • [38] Cytotoxic activity of lignans from Justicia procumbens
    Jin, Hong
    Yin, Hai-Long
    Liu, Shi-Jun
    Chen, Li
    Tian, Ying
    Li, Bin
    Wang, Qiong
    Dong, Jun-Xing
    FITOTERAPIA, 2014, 94 : 70 - 76
  • [39] Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity
    Berenice Aguilar-Guadarrama, A.
    Yolanda Rios, Maria
    MOLECULES, 2018, 23 (08)
  • [40] Synergistic antifungal activity of catechin and silver nanoparticles on Aspergillus niger isolated from coffee seeds br
    Molina-Hernandez, Junior Bernardo
    Scroccarello, Annalisa
    Della Pelle, Flavio
    De Flaviis, Riccardo
    Compagnone, Dario
    Del Carlo, Michele
    Paparella, Antonello
    Lopez, Clemencia Chaves
    LWT-FOOD SCIENCE AND TECHNOLOGY, 2022, 169
12345