Lignans from Trachelospermum jasminoides and Synergistic Antifungal Activity

被引：0
|
作者：
Guo, Liang-Jun [1 ,2 ]
Xu, Li-Ping [1 ,2 ]
Zheng, Wei [1 ,2 ]
Dong, Jia-Xiao [1 ,2 ,3 ]
Yi, Xian-Hui [4 ]
Jin, Yong-Sheng [3 ]
机构：
[1] Anhui Med Univ, PLA Clin Coll 98, Hosp PLA 98, Dept Pharm, Huzhou 313000, Zhejiang, Peoples R China
[2] Anhui Med Univ, PLA Clin Coll 98, Hosp PLA 98, Dept Pharm, Hefei 230032, Anhui, Peoples R China
[3] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
[4] Liwah Pharmaceut Co Ltd, Zhenhai Branch, Ningbo 315200, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 06期
关键词：
antifungal activity; lignans; synergy; Trachelospermum jasminoides; CANDIDA-ALBICANS RESISTANT; IN-VITRO SYNERGISM; CHEMICAL-CONSTITUENTS; FLUCONAZOLE; BAICALEIN; PLANTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The vines of Trachelospermum jasminoides (Lindl.) Lem. is used in folk medicine as aching of the waist and knee and traumatic injuries. This study isolated the lignans of leaves and stems and evaluated for their synergistic antifungal activity with fluconazole against fluconazole-resistant Candida albicans 103 in vitro. Seven lignans were isolated from the leaves and stems of T. jasminoides. The dimethylmatairesinol (7) was isolated from this genus for the first time. The results of synergistic antifungal activity with fluconazole against C. albicans 103 showed that all compounds except 2 and 7 exhibited good synergy in combination with fluconazole. Of these active compounds, 1, 5 and 6 (FICI = 0.125) showed more potent synergistic antifungal effects than baicalein (FICI = 0.188).
引用
收藏
页码：1236 / 1240
页数：5
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