Nickel-Catalysis Enabling α-Alkylation of Ketones by Secondary Alcohols

被引：15

作者：

Bains, Amreen K. ^{[1
]}

Biswas, Ayanangshu ^{[1
]}

Kundu, Abhishek ^{[1
]}

Adhikari, Debashis ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sas Nagar 140306, Punjab, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 16期

关键词：

Borrowing hydrogen; Secondary alcohol; Radical reaction; Azo-ligand redox; BORROWING HYDROGEN; DEHYDROGENATION; AUTOTRANSFER;

D O I：

10.1002/adsc.202200522

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The alpha-alkylation of ketones utilizing a secondary alcohol has been accomplished by an isolable, bench-stable, inexpensive nickel catalyst affording high yields of beta,beta-disubstituted products. This report contributes a nickel catalyst in the pool of a few scarce examples of base metal discovered for this purpose. The substrate scope can span a wide range including aliphatic, alicyclic, and cyclic secondary alcohols. Functionalization of a cholesterol molecule is also possible following this methodology. The catalyst can interconvert between azo and hydrazo form in a reversible fashion to enable this chemical transformation.

引用

页码：2815 / 2821

页数：7

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