The many roles of c-Myc in apoptosis

被引：279
作者：
Thompson, EB [1 ]
机构：
[1] Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77555 USA
来源：
ANNUAL REVIEW OF PHYSIOLOGY | 1998年 / 60卷
关键词：
apoptosis; c-myc; cell death; induction; repression;
D O I：
10.1146/annurev.physiol.60.1.575
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.
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收藏
页码：575 / 600
页数：26
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