Early elevated alkaline phosphatase increases the risk of large-for-gestational-age birth weight in pregnant women with normal glucose tolerance

被引：5

作者：

Liu, Yingfeng ^{[1
]}

Hou, Wolin ^{[1
]}

Meng, Xiyan ^{[2
]}

Zhao, Weijing ^{[1
]}

Pan, Jiemin ^{[1
]}

Tang, Junling ^{[1
]}

Huang, Yajuan ^{[2
]}

Li, Huaping ^{[2
]}

Tao, Minfang ^{[2
]}

Liu, Fang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6,Shanghai Inst Diabet, Shanghai Key Clin Ctr Metab Dis,Shanghai Clin Med, Shanghai Key Lab Diabet,Dept Endocrinol & Metab, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Clin Ctr Severe Maternal Rescue, Dept Obstet & Gynecol, Shanghai, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2018年 / 141卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Alkaline phosphatase; Large for gestational age; Insulin resistance; Inflammation; METABOLIC SYNDROME; LIVER-ENZYMES; CARDIOVASCULAR-DISEASE; HOMEOSTASIS; OUTCOMES; OBESITY; COHORT;

D O I：

10.1016/j.diabres.2018.04.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: The aim of this study was to assess the association between levels of alkaline phosphatase (ALP) in early pregnancy and the incidence of large-for-gestational-age (LGA) neonates in pregnant women without gestational diabetes mellitus. Methods: A prospective cohort was carried out in 544 women and their biochemical parameters including serum ALP and demographic characteristics were collected in 13-16th gestational week. At 24-28th weeks of gestation, 50 g oral glucose challenge test and oral 75 g glucose tolerance test was performed. LGA was defined as birth weight >= 90th percentile for completed week of gestational age based on the sex-specific growth curves. Logistic regression and receiver operating characteristic analysis were utilized to identify independent risk factors and odds ratio among ALP quartiles for incidence of LGA. Results: Women diagnosed as LGA held higher level of ALP than women in non-LGA group (P = 0.008). Moreover, ALP (odds ratio (OR) 1.05 [95% confidence interval (CI): 1.00, 1.10]) was the independent risk factors associated with LGA. Compared with ALP quartile 1, women in quartile 4 had more than 2.5-fold increased odds of LGA (OR 3.78, 95% CI: 1.10, 13.02), and the risk reached 4 times after adjusting several covariates (OR 4.15, 95% CI: 1.14,15.13). Conclusions: A significantly increased risk of LGA was associated with higher serum concentrations of ALP in pregnant women with NGT, even it is in normal reference range. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：209 / 216

页数：8

共 31 条

[11] Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies[J]. Jansson, Nina;Rosario, Fredrick J.;Gaccioli, Francesca;Lager, Susanne;Jones, Helen N.;Roos, Sara;Jansson, Thomas;Powell, Theresa L. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013(01)
[12] Fetal macrosomia and pregnancy outcomes[J]. Ju, Hong;Chadha, Yogesh;Donovan, Tim;O'Rourke, Peter. AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2009(05)
[13] Intestinal alkaline phosphatase prevents metabolic syndrome in mice[J]. Kaliannan, Kanakaraju;Hamarneh, Sulaiman R.;Economopoulos, Konstantinos P.;Alam, Sayeda Nasrin;Moaven, Omeed;Patel, Palak;Malo, Nondita S.;Ray, Madhury;Abtahi, Seyed M.;Muhammad, Nur;Raychowdhury, Atri;Teshager, Abeba;Mohamed, Mussa M. Rafat;Moss, Angela K.;Ahmed, Rizwan;Hakimian, Shahrad;Narisawa, Sonoko;Millan, Jose Luis;Hohmann, Elizabeth;Warren, H. Shaw;Bhan, Atul K.;Malo, Madhu S.;Hodin, Richard A. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013(17)
[14] Maternal Glycemia and Risk of Large-for-Gestational-Age Babies in a Population-Based Screening[J]. Kerenyi, Zsuzsa;Gyula Tamas;Kivimaki, Mika;Peterfalvi, Andrea;Madarasz, Eszter;Bosnyak, Zsolt;Tabak, Adam G. DIABETES CARE, 2009(12)
[15] Liver enzymes and risk of cardiovascular disease in the general population: A meta-analysis of prospective cohort studies[J]. Kunutsor, Setor K.;Apekey, Tanefa A.;Khan, Hassan. ATHEROSCLEROSIS, 2014(01)
[16] Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet[J]. Lalles, Jean-Paul. NUTRITION REVIEWS, 2010(06)
[17] Gestational diabetes: The consequences of not treating[J]. Langer, O;Yogev, Y;Most, O;Xenakis, EMJ. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2005(04)
[18] A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity[J]. Malo, Madhu S. EBIOMEDICINE, 2015(12)
[19] Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes[J]. Martino, J.;Sebert, S.;Segura, M. T.;Garcia-Valdes, L.;Florido, J.;Padilla, M. C.;Marcos, A.;Rueda, R.;McArdle, H. J.;Budge, H.;Symonds, M. E.;Campoy, C. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016(01)
[20] Insulin sensitivity indices obtained from oral glucose tolerance testing - Comparison with the euglycemic insulin clamp[J]. Matsuda, M;DeFronzo, RA. DIABETES CARE, 1999(09)

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