Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

被引：148

作者：

Chen, Kai ^{[1
]}

Zhang, Shuai ^{[1
]}

He, Pei ^{[1
]}

Li, Pengfei ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, FIST, Ctr Organ Chem, 99 Yanxiang Rd, Xian 710054, Shaanxi, Peoples R China

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 06期

关键词：

C-H BORYLATION; CROSS-COUPLING REACTIONS; ALKOXY DIBORON REAGENTS; CATALYZED BORYLATION; ROOM-TEMPERATURE; BOND FUNCTIONALIZATION; PHOTOREDOX CATALYSIS; ELECTRONIC-STRUCTURE; SELECTIVE REACTIONS; BORONIC ACID;

D O I：

10.1039/c5sc04521e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid, chemoselective and metal-free C-B bond-forming reaction of aryl iodides and bromides in aqueous solution at low temperatures was discovered. This reaction is amenable to batch and continuous-flow conditions and shows exceptional functional group tolerance and broad substrate scope regarding both the aryl halide and the borylating reagent. Initial mechanistic experiments indicated a photolytically generated aryl radical as the key intermediate.

引用

页码：3676 / 3680

页数：5

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