Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery

被引：27
作者：
Wang, Yu-Cai [3 ,4 ]
Wu, Juan [3 ,4 ]
Li, Yang [1 ,2 ]
Du, Jin-Zhi [3 ,4 ]
Yuan, You-Yong [1 ,2 ]
Wang, Jun [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
[3] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China
[4] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 20期
关键词：
SOLUTION BEHAVIOR; BLOCK-COPOLYMERS; NANOGELS; BIODEGRADATION; CARRIERS; RELEASE;
D O I：
10.1039/c002620d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the preparation of biodegradable nanoscopic hydrogels and their application for targeted drug delivery. The nanogel is synthesized in a template-free method by photo-crosslinking salt-induced polymer assemblies. With convenient incorporation of targeted lactosyl moieties, the nanogels efficiently deliver doxorubicin to HepG2 cells through receptor-mediated internalization.
引用
收藏
页码：3520 / 3522
页数：3
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