Retinal cell regeneration using tissue engineered polymeric scaffolds

被引：27
作者：
Zadeh, Maria Abedin [1 ,2 ]
Khoder, Mouhamad [1 ,2 ]
Ai-Kinani, Ali A. [1 ,2 ]
Younes, Husam M. [2 ,4 ]
Alany, Raid G. [1 ,2 ,3 ]
机构：
[1] Kingston Univ London, Sch Life Sci Pharm & Chem, Drug Discovery Delivery & Patient Care DDDPC Them, London, England
[2] Qatar Univ, Coll Pharm, Pharmaceut & Polymer Drug Delivery Res Lab, Doha, Qatar
[3] Univ Auckland, Sch Pharm, Auckland, New Zealand
[4] Qatar Univ, Off Vice President Res & Grad Studies, Doha, Qatar
来源：
DRUG DISCOVERY TODAY | 2019年 / 24卷 / 08期
关键词：
PLURIPOTENT STEM-CELLS; ANTERIOR LENS CAPSULE; MACULAR DEGENERATION; EXTRACELLULAR-MATRIX; PIGMENT EPITHELIUM; BRUCHS MEMBRANE; NANOFIBROUS SCAFFOLDS; IN-VITRO; ALGINATE; TRANSPLANTATION;
D O I：
10.1016/j.drudis.2019.04.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Degenerative retinal diseases, such as age-related macular degeneration (AMD), can lead to permanent sight loss. Although intravitreal anti-vascular endothelial growth factor (VEGF) and steroid injections are effective for the management of early stages of wet and/or neovascular AMD (nAMD), no proven treatments currently exist for dry AMD or for the advanced geographic atrophy of the retina that follows. Tissue engineering (TE) has recently emerged as a promising alternative to repair retinal damaged and restore its functions. Here, we review recent advances in TE, with a particular emphasis on retinal regeneration. We provide an overview of retinal diseases, followed by a comprehensive review of TE techniques, cells, and polymers used in the fabrication of scaffolds for retinal cell regenerations, in particular the retinal pigment epithelium (RPE).
引用
收藏
页码：1669 / 1678
页数：10
相关论文
共 108 条
  • [1] On the Effects of UV-C and pH on the Mechanical Behavior, Molecular Conformation and Cell Viability of Collagen-Based Scaffold for Vascular Tissue Engineering
    Achilli, Mateo
    Lagueux, Jean
    Mantovani, Diego
    [J]. MACROMOLECULAR BIOSCIENCE, 2010, 10 (03) : 307 - 316
  • [2] Effect of non-cross-linked calcium on characteristics, swelling behaviour, drug release and mucoadhesiveness of calcium alginate beads
    Al Dalaty, Adnan
    Karam, Ayman
    Najlah, Mohammad
    Alany, Raid G.
    Khoder, Mouhamad
    [J]. CARBOHYDRATE POLYMERS, 2016, 140 : 163 - 170
  • [3] Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD
    Algvere, PV
    Gouras, P
    Kopp, ED
    [J]. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 1999, 9 (03) : 217 - 230
  • [4] Transplantation of RPE in age-related macular degeneration: Observations in disciform lesions and dry RPE atrophy
    Algvere, PV
    Berglin, L
    Gouras, P
    Sheng, YH
    Kopp, ED
    [J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1997, 235 (03) : 149 - 158
  • [5] Electrospun Biopolyesters as Drug Screening Platforms for Corneal Keratocytes
    Azari, Pedram
    Luan, Ng Sook
    Gan, Seng Neon
    Yahya, Rosiyah
    Wong, Chiow San
    Chua, Kien Hui
    Pingguan-Murphy, Belinda
    [J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2015, 64 (15) : 785 - 791
  • [6] Mutations in IMPG2, Encoding Interphotoreceptor Matrix Proteoglycan 2, Cause Autosomal-Recessive Retinitis Pigmentosa
    Bandah-Rozenfeld, Dikla
    Collin, Rob W. J.
    Banin, Eyal
    van den Born, L. Ingeborgh
    Coene, Karlien L. M.
    Siemiatkowska, Anna M.
    Zelinger, Lina
    Khan, Muhammad I.
    Lefeber, Dirk J.
    Erdinest, Inbar
    Testa, Francesco
    Simonelli, Francesca
    Voesenek, Krysta
    Blokland, Ellen A. W.
    Strom, Tim M.
    Klaver, Caroline C. W.
    Qamar, Raheel
    Banfi, Sandro
    Cremers, Frans P. M.
    Sharon, Dror
    den Hollander, Anneke I.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 87 (02) : 199 - 208
  • [7] Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex
    Bhutto, Imran
    Lutty, Gerard
    [J]. MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (04) : 295 - 317
  • [8] Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: A prospective trial
    Binder, S
    Krebs, I
    Hilgers, RD
    Abri, A
    Stolba, U
    Assadoulina, A
    Kellner, L
    Stanzel, BV
    Jahn, C
    Feichtinger, H
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (11) : 4151 - 4160
  • [9] Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: A pilot study
    Binder, S
    Stolba, U
    Krebs, I
    Kellner, L
    Jahn, C
    Feichtinger, H
    Povelka, M
    Frohner, U
    Kruger, A
    Hilgers, RD
    Krugluger, W
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2002, 133 (02) : 215 - 225
  • [10] The dynamic nature of Bruch's membrane
    Booij, J. C.
    Baas, D. C.
    Beisekeeva, J.
    Gorgels, T. G. M. F.
    Bergen, A. A. B.
    [J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (01) : 1 - 18
12345678910