Current trends in nontuberculous mycobacteria infections in Canadian children: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study

被引：35

作者：

Pham-Huy, Anne ^{[1
]}

Robinson, Joan L. ^{[2
]}

Tapiero, Bruce ^{[3
]}

Bernard, Chantal ^{[4
]}

Daniel, Sam ^{[5
]}

Dobson, Simon ^{[6
]}

Dery, Pierre ^{[7
]}

Le Saux, Nicole ^{[8
]}

Embree, Joanne ^{[9
]}

Valiquette, Louis ^{[10
]}

Quach, Caroline ^{[1
,11
]}

机构：

[1] McGill Univ, Div Infect Dis, Dept Pediat, Montreal Childrens Hosp,Hlth Ctr, Montreal, PQ H3H 1P3, Canada

[2] Stollery Childrens Hosp, Dept Pediat, Div Infect Dis, Edmonton, AB, Canada

[3] CHU St Justine, Div Infect Dis, Dept Pediat, Montreal, PQ, Canada

[4] McGill Univ, Dept Clin Pathol, Montreal Childrens Hosp, Ctr Hlth, Montreal, PQ H3H 1P3, Canada

[5] McGill Univ, Dept Otol, Montreal Childrens Hosp, Ctr Hlth, Montreal, PQ H3H 1P3, Canada

[6] BC Childrens Hosp, Div Infect Dis, Dept Pediat, Vancouver, BC, Canada

[7] Univ Laval, Ctr Hosp Univ Quebec, Dept Pediat, Ste Foy, PQ G1K 7P4, Canada

[8] Childrens Hosp Eastern Ontario, Dept Pediat, Div Infect Dis, Ottawa, ON K1H 8L1, Canada

[9] Univ Manitoba, Dept Pediat, Winnipeg, MB R3T 2N2, Canada

[10] CHU Sherbrooke, Dept Microbiol, Sherbrooke, PQ J1H 5N4, Canada

[11] McGill Univ, Dept Microbiol, Montreal Childrens Hosp, Ctr Hlth, Montreal, PQ H3H 1P3, Canada

来源：

PAEDIATRICS & CHILD HEALTH | 2010年 / 15卷 / 05期

关键词：

Adenitis; Atypical mycobacteria; Management; Non-HIV; Nontuberculous mycobacteria; Treatment; CERVICOFACIAL LYMPHADENITIS; CERVICAL LYMPHADENITIS; CLARITHROMYCIN; MANAGEMENT; ADENITIS; THERAPY;

D O I：

10.1093/pch/15.5.276

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BACKGROUND: Nontuberculous mycohacteria (NTM) infections appear to be increasing in number and severity in developed countries worldwide Surgical excision has been considered die standard treatment for NTM lymphadenitis, but the use of medical therapy seems to be increasing OBJECTIVE: To determine the disease characteristics as well as the current therapeutic management of NTM Infections in Canadian children METHODS: Cases of definite or probable NTM infections were identified prospectively in children up to IS years of age seen in 10 Canadian paediatric tertiary care centres from September 2005 to August 2006 Clinical, microbiological and pathological data were collected RESULTS: A total of 60 cases were identified Data were complete for 45 patients, including 34 cases of lymphadenitis, four cases of skin and soft tissue infection, and seven cases of pulmonary NTM infection Seventy-nine per cent of children (27 of 34) with lymphadenitis had an unsuccessful course of antibiotics before diagnosis Sixty-eight per cent of purified protein derivative tests (15 of 22) were positive NTM was detected in 76% of samples (29 of 38), of which 62% were Mycobacterium avium complex All patients with lymphadenitis underwent surgical therapy and most patients (74%) also received antimicrobials CONCLUSIONS: Current trends indicate that the majority of die study centres :ire using medical therapy with variable regimen and duration as kin adjunct to surgical excision in the treatment of NTM lymphadenitis Larger numbers and longer follow-up tunes are needed to better evaluate the efficacy of medical therapy and outcome of disease A randomized controlled study comparing surgical therapy alone and chemotherapy for NTM lymphadenitis is required

引用

页码：276 / 282

页数：7