Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B

被引：11

作者：

Shigemura, Tomonari ^{[1
]}

Nakazawa, Yozo ^{[1
]}

Matsuda, Kazuyuki ^{[2
]}

Motobayashi, Mitsuo ^{[1
]}

Saito, Shoji ^{[1
]}

Koike, Kenichi ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2014年 / 29卷

关键词：

Mucormycosis; Lichtheimia; Cerebrospinal fluid; Quantitative PCR; Liposomal amphotericin B; EARLY-DIAGNOSIS; SERUM;

D O I：

10.1016/j.ijid.2014.10.019

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the case of a 19-year-old male with possible cerebral mucormycosis following chemotherapy. We detected a Lichtheimia DNA load of 2.0 x 10(4) copies/ml in cerebrospinal fluid (CSF), although a CSF culture showed no growth. After treatment with intravenous liposomal amphotericin B, the Lichtheimia DNA load fell below the detection limit, and at the same time the patient's headache and imaging findings improved. The quantification of Mucorales DNA in CSF may be useful for evaluating cerebral mucormycosis. (C) 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：200 / 202

页数：3

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