Molecular targeted therapies for pediatric atypical teratoid/rhabdoid tumors

被引：4

作者：

Zhang, Chang ^{[1
]}

Li, Hao ^{[1
]}

机构：

[1] Fudan Univ, Dept Neurosurg, Childrens Hosp, Shanghai 201102, Peoples R China

来源：

PEDIATRIC INVESTIGATION | 2022年 / 6卷 / 02期

关键词：

Atypical teratoid; rhabdoid tumors; SMARCB1; SMARCA4; SWI; SNF complex; Targeted molecular therapy; CENTRAL-NERVOUS-SYSTEM; PHASE-I TRIAL; TERATOID RHABDOID TUMORS; SUPPRESSOR SNF5 LEADS; SWI/SNF COMPLEXES; BRAIN-TUMORS; SOLID TUMORS; CHILDREN; RECURRENT; INHIBITOR;

D O I：

10.1002/ped4.12325

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognoses and challenging side effects. The pivotal genetic event in AT/RT pathogenesis comprises the inactivation of SMARCB1 or SMARCA4. Recent epigenetic studies have demonstrated mutual and subtype-specific epigenetic derangements that drive tumorigenesis; the exploitation of these potential targets might improve the dismal treatment outcomes of AT/RTs. This review aims to summarize the literature concerning targeted molecular therapies for pediatric AT/RTs.

引用

页码：111 / 122

页数：12

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