A computationally designed β-amino acid-containing miniprotein

被引：12

作者：

Bejger, Magdalena ^{[1
]}

Fortuna, Paulina ^{[2
,3
]}

Drewniak-Switalska, Magda ^{[2
]}

Plewka, Jacek ^{[4
]}

Rypniewski, Wojciech ^{[1
]}

Berlicki, Lukasz ^{[2
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-61704 Poznan, Poland

[2] Wroclaw Univ Sci & Technol, Dept Bioorgan Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Med Biochem, Pausteura 1, PL-50368 Wroclaw, Poland

[4] Jagiellonian Univ, Fac Chem, Gronostajowa 2, PL-30387 Krakow, Poland

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 49期

关键词：

ALPHA-HELIX MIMICRY; SMALL-ANGLE SCATTERING; CRYSTALLOGRAPHIC CHARACTERIZATION; SECONDARY STRUCTURES; PEPTIDE FOLDAMERS; NEUROPEPTIDE-Y; SEQUENCE; ANALOGS;

D O I：

10.1039/d1cc02192c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new miniprotein built from three helices, including one structure based on the alpha alpha beta alpha alpha alpha beta sequence pattern was developed. Its crystal structure revealed a compact conformation with a well-packed hydrophobic core of unprecedented structure. The miniprotein formed dimers that were stabilized by the interaction of their hydrophobic surfaces.

引用

页码：6015 / 6018

页数：4

共 44 条

[1] Residue-based control of helix shape in beta-peptide oligomers [J].

Appella, DH ;

Christianson, LA ;

Klein, DA ;

Powell, DR ;

Huang, XL ;

Barchi, JJ ;

Gellman, SH .

NATURE, 1997, 387 (6631) :381-384

[2] Replacement of Thr32 and GIn34 in the C-Terminal Neuropeptide Y Fragment 25-36 by cis-Cyclobutane and cis-Cyclopentane β-Amino Acids Shifts Selectivity toward the Y4 Receptor [J].

Berlicki, Lukasz ;

Kaske, Melanie ;

Gutierrez-Abad, Raquel ;

Bernhardt, Guenther ;

Illa, Ona ;

Ortuno, Rosa M. ;

Cabrele, Chiara ;

Buschauer, Armin ;

Reiser, Oliver .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (21) :8422-8431

[3] Unique α,β- and α,α,β,β-Peptide Foldamers Based on cis-β-Aminocyclopentanecarboxylic Acid [J].

Berlicki, Lukasz ;

Pilsl, Ludwig ;

Weber, Edit ;

Mandity, Istvan M. ;

Cabrele, Chiara ;

Martinek, Tamas A. ;

Fueloep, Ferenc ;

Reiser, Oliver .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (09) :2208-2212

[4] Peptides Containing β-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry [J].

Cabrele, Chiara ;

Martinek, Tamas A. ;

Reiser, Oliver ;

Berlicki, Lukasz .

JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (23) :9718-9739

[5] High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein [J].

Chiu, TK ;

Kubelka, J ;

Herbst-Irmer, R ;

Eaton, WA ;

Hofrichter, J ;

Davies, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7517-7522

[6] Crystallographic characterization of helical secondary structures in α/β-peptides with 1:1 residue alternation [J].

Choi, Soo Hyuk ;

Guzei, Ilia A. ;

Spencer, Lara C. ;

Gellman, Samuel H. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (20) :6544-6550

[7] Crystallographic Characterization of Helical Secondary Structures in 2:1 and 1:2 α/β-Peptides [J].

Choi, Soo Hyuk ;

Guzei, Ilia A. ;

Spencer, Lara C. ;

Gellman, Samuel H. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (08) :2917-2924

[8] Artificial Chemokines: Combining Chemistry and Molecular Biology for the Elucidation of Interleukin-8 Functionality [J].

David, Ralf ;

Guenther, Robert ;

Baurmann, Lars ;

Luehmann, Tessa ;

Seebach, Dieter ;

Hofmann, Hans-Joerg ;

Beck-Sickinger, Annette G. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (46) :15311-15317

[9] Surprisingly stable helical conformations in α/β-peptides by incorporation of cis-β-aminocyclopropane carboxylic acids [J].

De Pol, S ;

Zorn, C ;

Klein, CD ;

Zerbe, O ;

Reiser, O .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (04) :511-514

[10] Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics [J].

Drewniak, Magda ;

Weglarz-Tomczak, Ewelina ;

Ozga, Katarzyna ;

Rudzinska-Szostak, Ewa ;

Macegoniuk, Katarzyna ;

Tomczak, Jakub M. ;

Bejger, Magdalena ;

Rypniewski, Wojciech ;

Berlicki, Lukasz .

BIOORGANIC CHEMISTRY, 2018, 81 :356-361

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