Real-world Efficacy of Direct-Acting Antiviral Therapy for HCV Infection Affecting People Who Inject Drugs Delivered in a Multidisciplinary Setting

被引:39
作者
Alimohammadi, Arshia [1 ]
Holeksa, Julie [1 ]
Thiam, Astou [1 ]
Truong, David [1 ]
Conway, Brian [1 ]
机构
[1] Vancouver Infect Dis Ctr, 201-1200 Burrard St, Vancouver, BC V6Z 2C7, Canada
基金
加拿大健康研究院;
关键词
hepatitis C virus; interferon-free direct-acting antiviral therapy; multidisciplinary; PWID; C VIRUS-INFECTION; HEPATITIS-C; REIMBURSEMENT; SOFOSBUVIR; RESTRICTIONS;
D O I
10.1093/ofid/ofy120
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Many clinicians and insurance providers are reluctant to embrace recent guidelines identifying people who inject drugs (PWID) as a priority population to receive hepatitis C virus (HCV) treatment. The aim of this study was to evaluate the efficacy of direct-acting antiviral (DAA) HCV therapy in a real-world population comprised predominantly of PWID. Methods. A retrospective analysis was performed on all HCV-infected patients who were treated at the Vancouver Infectious Diseases Centre between March 2014 and December 2017. All subjects were enrolled in a multidisciplinary model of care, addressing medical, psychological, social, and addiction-related needs. The primary outcome was achievement of sustained virologic response (undetectable HCV RNA) 12 or more weeks after completion of HCV therapy (SVR-12). Results. Overall, 291 individuals were enrolled and received interferon-free DAA HCV therapy. The mean age was 54 years, 88% were PWID, and 20% were HCV treatment experienced. At data lock, 62 individuals were still on treatment and 229 were eligible for evaluation of SVR by intent-to-treat (ITT) analysis. Overall, 207 individuals achieved SVR (90%), with 13 losses to follow-up, 7 relapses, and 2 premature treatment discontinuations. ITT SVR analysis show that active PWID and treatment-naive patients were less likely to achieve SVR (P = .0185 and .0317, respectively). Modified ITT analysis of active PWID showed no difference in achieving SVR (P = .1157) compared with non-PWID. Conclusion. Within a multidisciplinary model of care, the treatment of HCV-infected PWID with all-oral DAA regimens is safe and highly effective. These data justify targeted efforts to enhance access to HCV treatment in this vulnerable and marginalized population.
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页数:7
相关论文
共 29 条
[1]   Continued low uptake of treatment for hepatitis C virus infection in a large community-based cohort of inner city residents [J].
Alavi, Maryam ;
Raffa, Jesse D. ;
Deans, Gregory D. ;
Lai, Calvin ;
Krajden, Mel ;
Dore, Gregory J. ;
Tyndall, Mark W. ;
Grebely, Jason .
LIVER INTERNATIONAL, 2014, 34 (08) :1198-1206
[2]  
Alimohammadi A., 2017, International journal of current advanced research, V6, P2075
[3]   Towards elimination of viral hepatitis by 2030 [J].
不详 .
LANCET, 2016, 388 (10042) :308-308
[4]  
[Anonymous], 2016, Recommendations for Testing, Managing, and Treating Hepatitis C
[5]  
Aspinall Alex I, 2018, CMAJ Open, V6, pE12, DOI 10.9778/cmajo.20170059
[6]   Impact of all oral anti-hepatitis C virus therapy: A metaanalysis [J].
Bansal, Siddharth ;
Singal, Ashwani K. ;
McGuire, Brendan M. ;
Anand, Bhupinder S. .
WORLD JOURNAL OF HEPATOLOGY, 2015, 7 (05) :806-813
[7]   Restrictions for Medicaid Reimbursement of Sofosbuvir for the Treatment of Hepatitis C Virus Infection in the United States [J].
Barua, Soumitri ;
Greenwald, Robert ;
Grebely, Jason ;
Dore, Gregory J. ;
Swan, Tracy ;
Taylor, Lynn E. .
ANNALS OF INTERNAL MEDICINE, 2015, 163 (03) :215-+
[8]  
Bennett JE, 2015, MANDELL DOUGLAS BENN, V34, P2157
[9]   Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study [J].
Blach, Sarah ;
Zeuzem, Stefan ;
Manns, Michael ;
Altraif, Ibrahim ;
Duberg, Ann-Sofi ;
Muljono, David H. ;
Waked, Imam ;
Alavian, Seyed M. ;
Lee, Mei-Hsuan ;
Negro, Francesco ;
Abaalkhail, Faisal ;
Abdou, Ahmed ;
Abdulla, Maheeba ;
Abou Rached, Antoine ;
Aho, Inka ;
Akarca, Ulus ;
Al Ghazzawi, Imad ;
Al Kaabi, Saad ;
Al Lawati, Faryal ;
Al Namaani, Khalid ;
Al Serkal, Youssif ;
Al-Busafi, Said A. ;
Al-Dabal, Layla ;
Aleman, Soo ;
Alghamdi, Abdullah S. ;
Aljumah, Abdulrahman A. ;
Al-Romaihi, Hamad E. ;
Andersson, Monique I. ;
Arendt, Vic ;
Arkkila, Perttu ;
Assiri, Abdullah M. ;
Baatarkhuu, Oidov ;
Bane, Abate ;
Ben-Ari, Ziv ;
Bergin, Colm ;
Bessone, Fernando ;
Bihl, Florian ;
Bizri, Abdul R. ;
Blachier, Martin ;
Blasco, Antonio J. ;
Mello, Carlos E. Brandao ;
Bruggmann, Philip ;
Brunton, Cheryl R. ;
Calinas, Filipe ;
Chan, Henry L. Y. ;
Chaudhry, Asad ;
Cheinquer, Hugo ;
Chen, Chien-Jen ;
Chien, Rong-Nan ;
Choi, Moon Seok .
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2017, 2 (03) :161-176
[10]  
del Rio-Valencia JC, 2018, REV ESP QUIM, V31, P35