Microbes of the human eye: Microbiome, antimicrobial resistance and biofilm formation

被引：10

作者：

Ranjith, Konduri ^{[1
]}

Sharma, Savitri ^{[1
]}

Shivaji, Sisinthy ^{[1
]}

机构：

[1] LV Prasad Eye Inst, Brien Holden Eye Res Ctr, Jhaveri Microbiol Ctr, Kallam Anji Reddy Campus, Hyderabad, Telangana, India

来源：

EXPERIMENTAL EYE RESEARCH | 2021年 / 205卷

关键词：

Ocular bacteria; Ocular microbiome; Anti-Microbial resistance; Biofilm; Biofilm stages; Biofilm genes; Antibiotic resistance genes; Ocular diseases; PSEUDOMONAS-AERUGINOSA BIOFILM; OCULAR SURFACE MICROBIOME; GLOBAL GENE-EXPRESSION; ESCHERICHIA-COLI K-12; VERSUS-HOST-DISEASE; POLYSACCHARIDE INTERCELLULAR ADHESIN; COAGULASE-NEGATIVE STAPHYLOCOCCI; CONJUNCTIVAL SAC MICROBIOME; STEVENS-JOHNSON SYNDROME; IN-VITRO SUSCEPTIBILITY;

D O I：

10.1016/j.exer.2021.108476

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Background: The review focuses on the bacteria associated with the human eye using the dual approach of detecting cultivable bacteria and the total microbiome using next generation sequencing. The purpose of this review was to highlight the connection between antimicrobial resistance and biofilm formation in ocular bacteria. Methods: Pubmed was used as the source to catalogue culturable bacteria and ocular microbiomes associated with the normal eyes and those with ocular diseases, to ascertain the emergence of anti-microbial resistance with special reference to biofilm formation. Results: This review highlights the genetic strategies used by microorganisms to evade the lethal effects of antimicrobial agents by tracing the connections between candidate genes and biofilm formation. Conclusion: The eye has its own microbiome which needs to be extensively studied under different physiological conditions; data on eye microbiomes of people from different ethnicities, geographical regions etc. are also needed to understand how these microbiomes affect ocular health.

引用

页数：20

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