IL-8/CXCR2 Signalling Promotes Cell Proliferation in Oesophageal Squamous Cell Carcinoma and Correlates With Poor Prognosis

被引：8

作者：

Inoue, Masazumi ^{[1
]}

Takeuchi, Hiroya ^{[2
]}

Matsuda, Sachiko ^{[1
]}

Nishi, Tomohiko ^{[1
]}

Fukuda, Kazumasa ^{[1
]}

Nakamura, Rieko ^{[1
]}

Takahashi, Tsunehiro ^{[1
]}

Wada, Norihito ^{[1
]}

Kawakubo, Hirofumi ^{[1
]}

Kitagawa, Yuko ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Surg, Tokyo, Japan

[2] Hamamatsu Univ, Sch Med, Dept Surg, Shizuoka, Japan

来源：

ANTICANCER RESEARCH | 2021年 / 41卷 / 02期

关键词：

Oesophageal squamous cell carcinoma; IL-8; CXCR2; chemokine; cell proliferation; WNT ANTAGONIST SFRP1; PHASE-III TRIAL; CXCR2; EXPRESSION; POSTOPERATIVE COMPLICATIONS; GASTROESOPHAGEAL JUNCTION; PREOPERATIVE CHEMOTHERAPY; EPIGENETIC INACTIVATION; CANCER; GROWTH; INTERLEUKIN-8;

D O I：

10.21873/anticanres.14830

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The inflammatory cytokine IL-8 and its receptor CXCR2 are key signalling pathway molecules in cancer development. We hypothesized that IL-8/CXCR2 signalling promotes tumour progression in oesophageal squamous cell carcinoma (ESCC) patients. Materials and Methods: We examined the relationship between IL-8/CXCR2 expression and clinicopathological factors by inununohistochemistry in samples from 63 patients with resectable ESCC. The effects of IL-8/CXCR2 signalling on cell proliferation and gene expression were examined in vitro and in vivo using ESCC cell lines. Results: Increased IL-8/CXCR2 signalling was associated with shorter overall survival (p<0.05) and recurrence-free survival (p<0.05) in ESCC patients. Multivariate analysis identified IL-8/CXCR2 expression as a prognostic factor for surgically treated ESCC (p<0.05). In vitro, IL-8 exposure or over-expression significantly enhanced ESCC cell proliferation. SB225002, a CXCR2-specific antagonist, and IL-8 siRNA significantly suppressed cell proliferation. Conclusion: IL-8/CXCR2 expression is an independent prognostic factor for surgically treated ESCC, and IL-8/CXCR2 signalling contributes to ESCC cell proliferation.

引用

页码：783 / 794

页数：12

共 34 条

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